A61K 38/465
Acting on ester bonds
Official title: {acting on ester bonds (3.1), e.g. lipases, ribonucleases}
A61K38/465 (Acting on ester bonds) appears on 1,307 US grants and 2,741 published applications in this corpus.
Search patents in A61K- Granted patents
- 1,307
- Published applications
- 2,741
- Assignees
- 928
- Inventors
- 4,031
- Latest grant
- 6 Oct 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1976 | 1 | 0 |
| 1977 | 1 | 0 |
| 1978 | 1 | 0 |
| 1979 | 0 | 0 |
| 1980 | 0 | 0 |
| 1981 | 1 | 0 |
| 1982 | 0 | 0 |
| 1983 | 1 | 0 |
| 1984 | 1 | 0 |
| 1985 | 1 | 0 |
| 1986 | 0 | 0 |
| 1987 | 0 | 0 |
| 1988 | 1 | 0 |
| 1989 | 3 | 0 |
| 1990 | 2 | 0 |
| 1991 | 2 | 0 |
| 1992 | 0 | 0 |
| 1993 | 6 | 0 |
| 1994 | 6 | 0 |
| 1995 | 4 | 0 |
| 1996 | 6 | 0 |
| 1997 | 14 | 0 |
| 1998 | 7 | 0 |
| 1999 | 10 | 0 |
| 2000 | 1 | 0 |
| 2001 | 6 | 6 |
| 2002 | 11 | 23 |
| 2003 | 10 | 28 |
| 2004 | 11 | 27 |
| 2005 | 6 | 27 |
| 2006 | 8 | 30 |
| 2007 | 6 | 29 |
| 2008 | 6 | 36 |
| 2009 | 6 | 45 |
| 2010 | 15 | 54 |
| 2011 | 20 | 61 |
| 2012 | 39 | 80 |
| 2013 | 36 | 90 |
| 2014 | 51 | 98 |
| 2015 | 67 | 137 |
| 2016 | 63 | 158 |
| 2017 | 74 | 155 |
| 2018 | 78 | 150 |
| 2019 | 90 | 171 |
| 2020 | 96 | 176 |
| 2021 | 97 | 222 |
| 2022 | 113 | 226 |
| 2023 | 72 | 192 |
| 2024 | 111 | 206 |
| 2025 | 88 | 186 |
| 2026 | 58 | 128 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- Method for modulating RNA splicing by inducing base mutation at splice site or base substitution in polypyrimidine region6 Oct 2026US 12,753,420 B2Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Engineered meganucleases having specificity for a recognition sequence in the transthyretin gene29 Sep 2026US 12,747,430 B2Precision BioSciences, Inc.
- Chimeric receptor binding proteins for use in bacterial delivery vehicles8 Sep 2026US 12,729,223 B2Eligo Bioscience
- Compositions and systems comprising transfection-competent vesicles free of organic-solvents and detergents and methods related thereto1 Sep 2026US 12,721,909 B2The University of British Columbia
- CRISPR-associated systems and components25 Aug 2026US 12,716,060 B2Arbor Biotechnologies, Inc.
- Novel glycan compounds for age-related macular degeneration8 Oct 2026US 2026/0306530 A1The Regents of the University of California
- Treating muscle weakness with alkaline phosphatases8 Oct 2026US 2026/0306590 A1
- Fusion proteins comprising cas enzymes and dna-binding proteins8 Oct 2026US 2026/0308557 A1Sarepta Therapeutics, Inc.
- Biallelic Knockout of ANGPTL38 Oct 2026US 2026/0308639 A1EmendoBio Inc.
- Universal treatment of down syndrome1 Oct 2026US 2026/0294978 A1DEI Biopharma
Most cited
By later US patents
- Three-dimensional polymer matrices268US 6,471,993 B1Massachusetts Institute of Technology · 2002
- Modulated release from biocompatible polymers263US 5,656,297 AAlkermes Controlled Therapeutics, Inc. · 1997
- Formulation of a reconstituted protein, and method and kit for the production thereof234US 5,580,856 A1996
- Modulated release from biocompatible polymers226US 5,912,015 AAlkermes Controlled Therapeutics, Inc. · 1999
- Engineered nucleic acids and methods of use thereof184US 9,464,124 B2Moderna Therapeutics, Inc. · 2016