Novel glycan compounds for age-related macular degeneration
AssigneeThe Regents of the University of California
InventorsChristopher B. Toomey, Jeffrey D. Esko
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Abstract
Compositions and methods and compositions for treating age-related macular degeneration comprising administering to a subject in need thereof an effective amount of a composition comprising an agent such as soluble glycan (e.g., heparan sulfate), to treat age-related macular degeneration by blocking the accumulation of lipoproteins within the eye, such as on Bruch's membrane.
Claims29
A method of preventing, delaying the progression of, or treating age-related macular degeneration (AMD) comprising administering to a subject in need thereof an effective amount of a composition effective to inhibit lipoprotein binding to an extracellular matrix of the eye.
A pharmaceutical composition comprising an amount of soluble glycan effective to inhibit lipoprotein binding to an extracellular matrix of the eye, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.