Engineered nucleic acids and methods of use thereof
AssigneeModerna Therapeutics, Inc.
InventorsStephane Bancel, Jason P. Schrum, Alexander Aristarkhov
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Abstract
Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of microorganisms. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent microbial infection, or to improve a subject's heath or wellbeing.
Claims17
A pharmaceutical composition comprising:
- a lipid-based nanoparticle comprising a synthetic messenger ribonucleic acid (mRNA) encoding a defensin polypeptide in an amount effective to permit production of the defensin polypeptide in a cell, wherein the synthetic mRNA comprises a translatable region that contains at least one nucleoside modification, and wherein 75-100% of uridine nucleotides in the synthetic mRNA are modified.
A kit comprising:
- (a) a synthetic messenger ribonucleic acid (mRNA) encoding a defensin polypeptide packaged in a container, wherein the synthetic mRNA comprises a translatable region that contains at least one nucleoside modification, and wherein 75-100% of uridine nucleotides in the synthetic mRNA are modified;
- and
- (b) a pharmaceutically acceptable carrier packaged in a container.
A lipid-based nanoparticle comprising a synthetic messenger ribonucleic acid (mRNA) encoding a defensin polypeptide in an amount effective to permit production of the defensin polypeptide in a cell,
- wherein 75-100% of uridine nucleotides in the synthetic mRNA are modified, and
- wherein the synthetic mRNA comprises a translatable region, a 5′ untranslated region and a 3′ untranslated region, each of which contains at least one nucleoside modification.
Dependencies are inferred from the claim text.