Treating muscle weakness with alkaline phosphatases
OwnerDenise DEVORE, Anna PETRYK +3inventors
InventorsDenise DEVORE, Anna PETRYK, Walter VOEGTLI, Derek DUNN, Juan RUANOVA
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Abstract
The disclosure features methods for treating or ameliorating at least one symptom of a subject having or being prone to a muscle weakness disease by administering to the subject a therapeutically effective amount of at least one recombinant polypeptide having alkaline phosphatase activity. The subject is characterized as lacking a loss-of-function mutation in an ALPL gene.
Claims68
A method of treating or reducing the risk of developing muscle weakness in a subject having or at risk of having a muscle weakness disease comprising administering to the subject a therapeutically effective amount of at least one recombinant polypeptide having alkaline phosphatase activity, wherein the subject exhibits a reduced concentration of tissue non-specific alkaline phosphatase (TNSALP), and wherein the subject does not have a loss-of-function mutation in an ALPL gene.
Dependencies are inferred from the claim text.