A61K 31/495
Having six-membered rings with two or more nitrogen atoms as the only
Official title: having six-membered rings with two {or more} nitrogen atoms as the only ring heteroatoms, e.g. piperazine {or tetrazines}(A61K31/48 takes precedence {; with three nitrogen atoms A61K31/53})
A61K31/495 (Having six-membered rings with two or more nitrogen atoms as the only) appears on 29,130 US grants and 53,740 published applications in this corpus.
Search patents in A61K- Granted patents
- 29,130
- Published applications
- 53,740
- Assignees
- 11,408
- Inventors
- 80,339
- Latest grant
- 6 Oct 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1976 | 79 | 0 |
| 1977 | 49 | 0 |
| 1978 | 31 | 0 |
| 1979 | 30 | 0 |
| 1980 | 29 | 0 |
| 1981 | 51 | 0 |
| 1982 | 30 | 0 |
| 1983 | 31 | 0 |
| 1984 | 40 | 0 |
| 1985 | 32 | 0 |
| 1986 | 36 | 0 |
| 1987 | 53 | 0 |
| 1988 | 64 | 0 |
| 1989 | 86 | 0 |
| 1990 | 88 | 0 |
| 1991 | 91 | 0 |
| 1992 | 103 | 0 |
| 1993 | 113 | 0 |
| 1994 | 91 | 0 |
| 1995 | 116 | 0 |
| 1996 | 163 | 0 |
| 1997 | 239 | 0 |
| 1998 | 280 | 0 |
| 1999 | 305 | 0 |
| 2000 | 328 | 0 |
| 2001 | 396 | 124 |
| 2002 | 420 | 597 |
| 2003 | 379 | 974 |
| 2004 | 301 | 1117 |
| 2005 | 314 | 1152 |
| 2006 | 393 | 1197 |
| 2007 | 270 | 1066 |
| 2008 | 306 | 1167 |
| 2009 | 341 | 1220 |
| 2010 | 485 | 1436 |
| 2011 | 529 | 1561 |
| 2012 | 719 | 1578 |
| 2013 | 1046 | 2136 |
| 2014 | 1342 | 2765 |
| 2015 | 1726 | 2944 |
| 2016 | 1773 | 2910 |
| 2017 | 1993 | 2944 |
| 2018 | 1883 | 2717 |
| 2019 | 1912 | 2908 |
| 2020 | 1810 | 2933 |
| 2021 | 1640 | 2905 |
| 2022 | 1509 | 3010 |
| 2023 | 1262 | 3075 |
| 2024 | 1354 | 3356 |
| 2025 | 1410 | 3300 |
| 2026 | 1059 | 2648 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Subgroups
Granted patents
- A61K 31/505Pyrimidines19,924
- A61K 31/496Non-condensed piperazines containing further heterocyclic rings6,031
- A61K 31/50Pyridazines2,934
- A61K 31/4965Non-condensed pyrazines2,475
- A61K 31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems2,127
- A61K 31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems1,077
- A61K 31/4995Pyrazines or piperazines forming part of bridged ring systems194
- A61K 31/499Spiro-condensed pyrazines or piperazines89
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Most cited
By later US patents
- Wound dressing with conformable elastomeric wound contact layer1,263US 5,445,604 ASmith and Nephew Associated Companies Limited · 1995
- Anti-angiogenic compositions and methods of use968US 5,716,981 AAngiogenesis Technologies, Inc. · 1998
- Solid carriers for improved delivery of active ingredients in pharmaceutical compositions930US 6,248,363 B1Lipocine Inc. · 2001
- Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation733US 9,101,621 B2Celgene Corporation · 2015
- Solid carriers for improved delivery of active ingredients in pharmaceutical compositions684US 6,923,988 B2Lipocine Inc. · 2005