A61K 31/498
Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems
Official title: Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
A61K31/498 (Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems) appears on 1,077 US grants and 2,122 published applications in this corpus.
Search patents in A61K- Granted patents
- 1,077
- Published applications
- 2,122
- Assignees
- 838
- Inventors
- 4,405
- Latest grant
- 6 Oct 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1995 | 2 | 0 |
| 1996 | 4 | 0 |
| 1997 | 6 | 0 |
| 1998 | 14 | 0 |
| 1999 | 11 | 0 |
| 2000 | 9 | 0 |
| 2001 | 14 | 6 |
| 2002 | 19 | 24 |
| 2003 | 16 | 52 |
| 2004 | 9 | 57 |
| 2005 | 14 | 59 |
| 2006 | 20 | 59 |
| 2007 | 8 | 54 |
| 2008 | 16 | 62 |
| 2009 | 11 | 36 |
| 2010 | 28 | 69 |
| 2011 | 22 | 57 |
| 2012 | 41 | 55 |
| 2013 | 44 | 85 |
| 2014 | 55 | 109 |
| 2015 | 63 | 127 |
| 2016 | 82 | 117 |
| 2017 | 81 | 125 |
| 2018 | 83 | 120 |
| 2019 | 77 | 102 |
| 2020 | 65 | 108 |
| 2021 | 53 | 95 |
| 2022 | 39 | 98 |
| 2023 | 51 | 111 |
| 2024 | 51 | 125 |
| 2025 | 41 | 116 |
| 2026 | 28 | 94 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- Methods and compositions for treating fungal infections6 Oct 2026US 12,751,944 B2Neoculi Pty Ltd
- RNA-targeting ligands, compositions thereof, and methods of making and using the same22 Sep 2026US 12,741,945 B2The University of North Carolina at Chapel Hill
- Pyrazolyl quinoxaline kinase inhibitors22 Sep 2026US 12,741,956 B2Astex Therapeutics Limited
- Certain 2,5-diazabicyclo[4.2.0]octanes and octahydrofuro[3,4-b]pyrazines as GLP-1 receptor modulators22 Sep 2026US 12,741,971 B2AstraZeneca AB
- Quinoxaline derivatives and uses thereof22 Sep 2026US 12,741,976 B2Black Diamond Therapeutics, Inc.
- Composition for removing and inhibiting senescent cells, and uses thereof8 Oct 2026US 2026/0306460 A1Lifeceutix Co., Ltd.
- Plasmin-induced internal limiting membrane digestion facilitates donor retinal ganglion cell transplantation8 Oct 2026US 2026/0306549 A1University of Pittsburgh—Of the Commonwealth System of Higher Education
- Oxazolopyridin-7(4h)-one wrn inhibitors8 Oct 2026US 2026/0308173 A1Nimbus Wadjet, Inc.
- Thiazolopyridin-7(4h)-one wrn inhibitors8 Oct 2026US 2026/0308177 A1Nimbus Wadjet, Inc.
- Inhibitors of spinster homolog 2 (spns2) for use in therapy1 Oct 2026US 2026/0297044 A1University of Virginia Patent Foundation
Most cited
By later US patents
- Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase209US 5,409,930 ARhone-Poulenc Rorer Pharmaceuticals Inc. · 1995
- Urologic irrigation solution and method for inhibition of pain, inflammation and spasm152US 5,858,017 AOmeros Medical Systems, Inc. · 1999
- Arthroscopic irrigation solution and method for inhibition of pain and inflammation140US 5,860,950 AOmeros Medical Systems, Inc. · 1999
- Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes140US 6,699,871 B2Merck & Co., Inc. · 2004
- Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase132US 5,656,643 ARhone-Poulenc Rorer Pharmaceuticals Inc. · 1997