Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
AssigneeRhone-Poulenc Rorer Pharmaceuticals Inc.
InventorsAlfred P. Spada, Martin P. Maquire, Paul E. Persons, Michael R. Myers
Life of this patent
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Abstract
This invention relates to bis mono- and/or bicyclic aryl and/or heteroaryl compounds exhibiting protein tyrosine kinase inhibition activity. More specifically, it relates to the method of inhibiting abnormal cell proliferation in a patient suffering from a disorder characterized by such proliferation comprising the administration thereto of an EGF and/or PDGF receptor inhibiting effective amount of said bis mono- and/or bicyclic aryl and/or heteroaryl compound and to the preparation of said compounds and their use in pharmaceutical compositions used in this method.
Claims13
A compound selected from the group consisting of:
- 3-(thien-3-yl)-6,7-dimethoxyquinoline;
- 3-(thien-3-yl)-7-methoxyquinoline;
- 3-(4-methoxyphenyl)-6,7-dimethoxyquinoline;
- 3-(5-chlorothien-2-yl)-6,7-dimethoxyquinoline;
- 3-(3-fluoro-4-methoxyphenyl)-6,7-dimethoxyquinoline;
- 3-(2-chlorothien-2-yl)-5,7-dimethoxyquinoline;
- 3-(thien-3-yl)-6,7-dimethylquinoline;
- 3-(1-cyclopent-1-enyl)-6,7-dimethoxyquinoline;
- 3-cyclopentyl-6,7-dimethoxyquinoline;
- 4-(3-phenylpropyloxy)-6,7-dimethoxyquinoline;
- 3-(thien-3-yl)-6,7-dimethoxyquinoline-N-oxide;
- 3-(2-chlorothien-5-yl)-5,7-dimethoxyquinoline;
- 3-(3-fluoro-4-methoxyphenyl)-6,7-dimethoxyquinoline;
- 3-(3-fluorophenyl)-6,7-dimethoxyquinoline;
- 4-(2-phenylethoxy)-6,7-dimethoxyquinoline;
- 3-(4-methoxybenzyloxy)-6,7-dimethoxyquinoline;
- 2-(4-methoxyphenyl)-6,7-dimethoxyquinoxaline;
- 2-(thien-3-yl)-6,7-dimethoxyquinoxaline;
- 2-phenyl-6,7-dimethoxyquinoxaline;
- 6. 7-dimethyl-2-(thien-3-yl)-quinoxaline;
- 2-phenyl-6,7-diethoxyquinoxaline;
- 2-(3-thienyl)-6,7-diethoxyquinoxaline;
- 2-(5-chloro-2-thienyl)-6,7-diethoxyquinoxaline;
- 2-(5-chloro-2-thienyl)-6,7-dimethoxyquinoxaline;
- 3-(3-fluoro-4-methoxyphenyl)-7-fluoroquinoline;
- 3-(thien-3-yl)-5,7-dimethylquinoline;
- 3-(5-chlorothien-2-yl)-6,7-dimethylquinoline;
- 3-(thien-3-yl)-6,7-difluoroquinoline or
- 3-(4-methoxyphyenyl)-7-methoxy-1-naphthalenol.
Dependencies are inferred from the claim text.