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US 12,741,945 B2Granted
RNA-targeting ligands, compositions thereof, and methods of making and using the same
AssigneeThe University of North Carolina at Chapel Hill
InventorsKevin Weeks, Jeffrey Aubé, Kelin Li, Meredith Zeller
Life of this patent
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Abstract
The disclosure is directed to compounds that bind to a target RNA molecule, such as a TPP riboswitch, compositions comprising the compounds, and methods of making and using the same. The compounds contain two structurally different fragments that allow for binding with the target RNA at two different binding sites thereby producing a higher affinity binding ligand compared to compounds that only bind to a single RNA binding site.
Claims16
A compound with a structure of formula (III):
- wherein
- L is selected from
- wherein q and r are independently selected from integers 0, 1, 2 and 3;
- and z is selected from integers 1, 2 and 3;
- and
- A is selected from
3 more elements
Dependencies are inferred from the claim text.