Anti-angiogenic compositions and methods of use
AssigneeAngiogenesis Technologies, Inc.
InventorsWilliam L. Hunter, Lindsay S. Machan, A. Larry Arsenault
Life of this patent
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Abstract
The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.
Claims18
a stent for expanding the lumen of a body passageway, comprising a generally tubular structure coated with a composition comprising paclitaxel, an analogue or derivative thereof, and a polymeric carrier.
a method for expanding the lumen of a body passageway, comprising inserting a stent into the passageway, the stent having a generally tubular structure coated with a composition comprising paclitaxel, an analogue or derivative thereof, and a polymeric carrier, such that said passageway is expanded.
a method for eliminating vascular obstructions, comprising inserting a vascular stent into a vascular passageway, the stent having a generally tubular structure coated with a composition comprising paclitaxel, an analogue or derivative thereof, and a polymeric carrier, such that said vascular obstruction is eliminated.
a method for eliminating biliary obstructions, comprising inserting a biliary stent into a biliary passageway, the stent having a generally tubular structure coated with a composition comprising paclitaxel, an analogue or derivative thereof, and a polymeric carrier, such that said biliary obstruction is eliminated.
a method for eliminating urethral obstructions, comprising inserting a urethral stent into a urethra, the stent having a generally tubular structure coated with a composition comprising paclitaxel, an analogue or derivative thereof, and a polymeric carrier, such that said urethral obstruction is eliminated.
a method for eliminating esophageal obstructions, comprising inserting an esophageal stent into an esophagus, the stent having a generally tubular structure coated with a composition comprising paclitaxel, an analogue or derivative thereof, and a polymeric carrier, such that said esophageal obstruction is eliminated.
a method for eliminating tracheal/bronchial obstructions, comprising inserting a tracheal/bronchial stent into the trachea or bronchi, the stent having a generally tubular structure coated with a composition comprising paclitaxel, an analogue or derivative thereof, and a polymeric carrier, such that said tracheal/bronchial obstruction is eliminated.
a method for treating or preventing narrowing of a blood vessel, comprising inserting a stent having a generally tubular structure coated with a composition comprising paclitaxel, an analogue or derivative thereof, and a polymeric carrier, such that said narrowing is treated or prevented.
Dependencies are inferred from the claim text.