Drug-polymer amorphous solid dispersions using linear polyacrylic acid polymers

An amorphous solid dispersion comprising:

• at least 10 wt. % of a linear poly(acrylic acid);
• and
• an active pharmaceutical ingredient, wherein:
• the active pharmaceutical ingredient is in BCS class II or BCS class IV;
• the linear poly(acrylic acid) has a Brookfield viscosity at 25° C. of from 100 cP to 1,000 cP as determined when dissolved in an aqueous solution containing about 4 wt. % of the poly(acrylic acid) at pH 7.5,
• the linear poly(acrylic acid) and the active pharmaceutical ingredient together comprise at least 80 wt. % of the amorphous solid dispersion,
• the linear poly(acrylic acid) has a weight average molecular weight, as determined by size exclusion chromatography on a liquid sample of 1.5 g/L polymer in 0.1M NaNO3 at pH 10, of between 200,000 Da and 1,500,000 Da, and
• a ratio by weight of the active pharmaceutical ingredient to the poly(acrylic acid) in the amorphous solid dispersion of at least 3:1 and up to 6:1.