Methods of preventing post-traumatic osteoarthritis using metformin
OwnerDiane Renee Wagner, Todd McKinley +3inventors
InventorsDiane Renee Wagner, Todd McKinley, Roman Michael Natoli, Uma Sankar-Davis, Sonali J. Karnik
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Abstract
Disclosed herein are methods of using metformin or a pharmaceutically acceptable salt thereof, such as intraarticular administration of metformin, to treat injured joints. Also disclosed are methods of using metformin to prevent the progression of osteoarthritis, such as osteoarthritis resulting from an injury, or post-traumatic osteoarthritis. Further disclosed are dosing regimens and compositions of metformin for the treatment and prevention of post-traumatic osteoarthritis.
Claims20
A method of treating an injured joint in a mammal, comprising administering an injectable composition comprising a pharmaceutically acceptable salt of metformin at a concentration of 25 mM to 150 mM to the injured joint via intraarticular injection.
An injectable composition, consisting essentially of hyaluronic acid or a salt thereof, wherein the salt is sodium hyaluronate or potassium hyaluronate, and at least 50 mM of a pharmaceutically acceptable salt of metformin, wherein the pharmaceutically acceptable salt of metformin is metformin hydrochloride, and the composition is suitable for intraarticular injection.
Dependencies are inferred from the claim text.