C12P 35/04
Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system: by acylation
Official title: by acylation of the substituent in the 7 position
C12P35/04 (Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system: by acylation) appears on 27 US grants and 12 published applications in this corpus.
Search patents in C12P- Granted patents
- 27
- Published applications
- 12
- Assignees
- 16
- Inventors
- 78
- Latest grant
- 18 Nov 2025
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1976 | 1 | 0 |
| 1977 | 0 | 0 |
| 1978 | 1 | 0 |
| 1979 | 0 | 0 |
| 1980 | 0 | 0 |
| 1981 | 0 | 0 |
| 1982 | 1 | 0 |
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| 1993 | 2 | 0 |
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| 1999 | 2 | 0 |
| 2000 | 2 | 0 |
| 2001 | 3 | 0 |
| 2002 | 2 | 1 |
| 2003 | 0 | 1 |
| 2004 | 0 | 0 |
| 2005 | 0 | 1 |
| 2006 | 0 | 1 |
| 2007 | 1 | 0 |
| 2008 | 0 | 1 |
| 2009 | 1 | 0 |
| 2010 | 0 | 1 |
| 2011 | 1 | 2 |
| 2012 | 0 | 0 |
| 2013 | 2 | 0 |
| 2014 | 0 | 1 |
| 2015 | 0 | 0 |
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| 2017 | 0 | 1 |
| 2018 | 0 | 0 |
| 2019 | 0 | 0 |
| 2020 | 0 | 0 |
| 2021 | 0 | 0 |
| 2022 | 0 | 0 |
| 2023 | 0 | 0 |
| 2024 | 0 | 0 |
| 2025 | 1 | 0 |
| 2026 | 0 | 2 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- One-step method for synthesizing amoxicillin from penicillin or salt thereof through enzyme catalysis18 Nov 2025US 12,473,580 B1Xingzhi College Zhejiang Normal University
- Mutant penicillin G acylases24 Sep 2013US 8,541,199 B2DSM Sinochem Pharmaceuticals Netherlands B.V.
- Process for the preparation of beta-lactam compounds30 Jul 2013US 8,497,088 B2DSM Sinochem Pharmaceuticals Netherlands B.V.
- Process for the synthesis of cefaclor6 Dec 2011US 8,071,330 B2Dsm IP Assets B.V.
- Process for the preparation of cephradine15 Sep 2009US 7,588,913 B2Dsm IP Assets B.V.
- Biosynthesis of beta-lactam antibiotics24 Sep 2026US 2026/0286334 A1
- Mutant penicillin acylase and uses thereof30 Apr 2026US 2026/0117216 A1Xingzhi College Zhejiang Normal University
- Salt of phenylglycine methyl ester19 Oct 2017US 2017/0298406 A1DSM Sinochem Pharmaceuticals Netherlands B.V.
- Process for preparing 3'-thiosubstituted cephalosporins employing a pencillin g acylase17 Jul 2014US 2014/0200342 A1DSM Sinochem Pharmaceuticals Netherlands B.V.
- Mutant penicillin g acylases20 Oct 2011US 2011/0256585 A1DSM Sinochem Pharmaceuticals Netherlands B.V.
Most cited
By later US patents
- Cephalosporin C acylase17US 5,192,678 AFujisawa Pharmaceutical Co., Ltd. · 1993
- Method for the production of cephalosporins15US 3,945,888 ATakeda Chemical Industries, Ltd. · 1976
- Cephalosporin C acylase12US 5,320,948 AFujisawa Pharmaceutical Co., Ltd. · 1994
- D-amino acid aminotransferase for simultaneously producing glutaryl-7-aminocephalosporanic acid and D-amino acid10US 6,337,190 B12002
- Enzymatic synthesis of .beta.-lactam antibacterials9US 4,340,672 AShionogi & Co., Ltd. · 1982