Process for the preparation of beta-lactam compounds
AssigneeDSM Sinochem Pharmaceuticals Netherlands B.V.
InventorsThomas Van Der Does, Harold Monro Moody, Theodorus Johannes Godfried Maria Van Dooren
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Abstract
The present invention describes a process for the synthesis of a semi-synthetic β-lactam compound from a nucleus and a side chain selected from the group consisting of D-phenylglycine and D-dihydro-phenylglycine in the form of a side chain ester and an enzyme catalyzing the coupling of the side chain ester to the nucleus characterized in that the side chain ester is not isolated as a solid intermediate.
Claims9
A process for the synthesis of a semi-synthetic β-lactam compound from a nucleus and a side chain selected from the group consisting of D-phenylglycine and D-dihydro-phenylglycine in the form of a side chain ester and an enzyme catalyzing the coupling of the side chain ester to the nucleus comprising the steps of
- (a) converting a free side chain selected from the group consisting of D-phenylglycine and D-dihydro-phenylglycine with an alcohol to form a mixture comprising the corresponding side chain ester;
- (b) forming the semi-synthetic β-lactam compound by mixing the mixture obtained in step (a) with a nucleus and the enzyme to form the semi-synthetic β-lactam compound,
- with the proviso that the side chain ester formed in step (a) is not isolated as a solid intermediate.
Dependencies are inferred from the claim text.