Salt of phenylglycine methyl ester
AssigneeDSM Sinochem Pharmaceuticals Netherlands B.V.
InventorThomas Van Der Does
Life of this patent
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Abstract
The present invention relates to the hemi sulfuric acid salt of D-phenylglycine methyl ester, to a method for the preparation of said salt and to the use of said salt in the enzymatic synthesis of antibiotics and of D-phenylglycine methyl ester free base.
Claims14
The hemi sulfuric acid salt of D-phenylglycine methyl ester.
A method for the preparation of the hemi sulfuric acid salt of D-phenylglycine methyl ester comprising the steps of:
- (a) contacting a solution of D-phenylglycine methyl ester in an organic solvent with sulfuric acid;
- (b) isolating the hemi sulfuric acid salt of D-phenylglycine methyl ester from the mixture obtained in step (a),
- wherein the molar amount of sulfuric acid in step (a) is from 0.4 to 0.6 relative to the molar amount of D-phenylglycine methyl ester.
A method for preparing one or more of ampicillin, cefaclor or cephalexin comprising contacting the hemi sulfuric acid salt of D-phenylglycine methyl ester with 6-aminopenicillanic acid, 7-amino-3-chloro-3-cephem-4-carboxylate or 7-aminodeacetoxycephalosporanic acid, respectively in the presence of a penicillin acylase.
(canceled)
Dependencies are inferred from the claim text.