C12N 15/1058
Directional evolution of libraries
Official title: {Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms}
C12N15/1058 (Directional evolution of libraries) appears on 485 US grants and 816 published applications in this corpus.
Search patents in C12N- Granted patents
- 485
- Published applications
- 816
- Assignees
- 331
- Inventors
- 1,347
- Latest grant
- 9 Jun 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1995 | 1 | 0 |
| 1996 | 2 | 0 |
| 1997 | 1 | 0 |
| 1998 | 5 | 0 |
| 1999 | 1 | 0 |
| 2000 | 4 | 0 |
| 2001 | 9 | 4 |
| 2002 | 21 | 12 |
| 2003 | 12 | 25 |
| 2004 | 5 | 15 |
| 2005 | 7 | 26 |
| 2006 | 8 | 30 |
| 2007 | 7 | 18 |
| 2008 | 6 | 20 |
| 2009 | 9 | 20 |
| 2010 | 17 | 22 |
| 2011 | 10 | 17 |
| 2012 | 6 | 28 |
| 2013 | 8 | 29 |
| 2014 | 24 | 26 |
| 2015 | 21 | 38 |
| 2016 | 28 | 43 |
| 2017 | 30 | 36 |
| 2018 | 25 | 31 |
| 2019 | 22 | 35 |
| 2020 | 25 | 57 |
| 2021 | 38 | 54 |
| 2022 | 28 | 47 |
| 2023 | 30 | 56 |
| 2024 | 30 | 53 |
| 2025 | 26 | 44 |
| 2026 | 19 | 30 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- Unified platform for rapid production of nanovaccines with enhanced safety, efficacy and precision9 Jun 2026US 12,651,648 B2Santa Clara University
- AAV3B variants that target hepatocytes and evade the humoral immune response2 Jun 2026US 12,644,132 B2University of Florida Research Foundation, Inc.
- Compositions and methods of treatment19 May 2026US 12,630,805 B2The Regents of the University of California
- Fluorescent proteins and split fluorescent proteins from corynactis californica and methods of use19 May 2026US 12,630,817 B1Triad National Security, LLC
- Methods for analyzing nucleic acids19 May 2026US 12,630,866 B2Biomodal Limited
- System, Kit, and Method for Continuous Directed Evolution8 Oct 2026US 2026/0308569 A1The Board of Trustees of the University of Illinois
- Vectors expressing color and selectable markers17 Sep 2026US 2026/0275329 A1The Trustees of Indiana University
- Method for production of virus-like particles for gene delivery27 Aug 2026US 2026/0250644 A1Carnegie Mellon University
- Circular rna vectors comprising modified nucleotides20 Aug 2026US 2026/0242805 A1University of Massachusetts
- Methods and compositions for treating alpha-1 antitrypsin deficiency6 Aug 2026US 2026/0224748 A1Beam Therapeutics Inc.
Most cited
By later US patents
- Methods and compositions for cellular and metabolic engineering844US 5,837,458 AMaxygen, Inc. · 1998
- Methods for generating polynucleotides having desired characteristics by iterative selection and recombination531US 6,117,679 AMaxygen, Inc. · 2000
- Methods and compositions for polypeptide engineering338US 6,586,182 B1Maxygen, Inc. · 2003
- Methods for generating polynucleotides having desired characteristics by iterative selection and recombination322US 6,165,793 AMaxygen, Inc. · 2000
- In vitro evolution in microfluidic systems319US 7,968,287 B2Medical Research Council Harvard University · 2011