C12N 15/1024
In vivo mutagenesis using high mutation rate "mutator" host strains by inserting
Official title: {In vivo mutagenesis using high mutation rate "mutator" host strains by inserting genetic material, e.g. encoding an error prone polymerase, disrupting a gene for mismatch repair}
C12N15/1024 (In vivo mutagenesis using high mutation rate "mutator" host strains by inserting) appears on 172 US grants and 271 published applications in this corpus.
Search patents in C12N- Granted patents
- 172
- Published applications
- 271
- Assignees
- 124
- Inventors
- 400
- Latest grant
- 18 Aug 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1998 | 1 | 0 |
| 1999 | 0 | 0 |
| 2000 | 1 | 0 |
| 2001 | 0 | 0 |
| 2002 | 0 | 3 |
| 2003 | 0 | 5 |
| 2004 | 2 | 3 |
| 2005 | 1 | 6 |
| 2006 | 2 | 2 |
| 2007 | 2 | 4 |
| 2008 | 2 | 5 |
| 2009 | 2 | 4 |
| 2010 | 6 | 5 |
| 2011 | 2 | 4 |
| 2012 | 3 | 3 |
| 2013 | 3 | 2 |
| 2014 | 2 | 8 |
| 2015 | 4 | 13 |
| 2016 | 12 | 16 |
| 2017 | 12 | 21 |
| 2018 | 5 | 19 |
| 2019 | 20 | 27 |
| 2020 | 20 | 36 |
| 2021 | 11 | 16 |
| 2022 | 19 | 17 |
| 2023 | 15 | 15 |
| 2024 | 8 | 21 |
| 2025 | 12 | 10 |
| 2026 | 5 | 6 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- Cancer treatment through RLIP76 partial depletion18 Aug 2026US 12,709,746 B2Board of Regents, The University of Texas System
- RNA-guided human genome engineering9 Jun 2026US 12,649,928 B2President and Fellows of Harvard College
- RNA-guided human genome engineering28 Apr 2026US 12,612,643 B2President and Fellows of Harvard College
- Self-diversifying systems and methods of use thereof21 Apr 2026US 12,606,815 B2Massachusetts Institute of Technology
- System for inducing mutation based on optimized activation-induced cytidine deaminase17 Mar 2026US 12,577,553 B2Sun Yat-Sen University
- EvolvR Polypeptides and Methods of Use Thereof23 Jul 2026US 2026/0209758 A1
- RNA-Guided Human Genome Engineering23 Jul 2026US 2026/0209792 A1President and Fellows of Harvard College
- RNA-Guided Endonuclease Fusion Polypeptides and Methods of Use Thereof14 May 2026US 2026/0132390 A1The Regents of the University of California
- Methods and compositions for synthetic evolution7 May 2026US 2026/0125669 A1Universitat Pompeu Fabra
- Methods and products for expressing proteins in cells19 Mar 2026US 2026/0078413 A1Factor Bioscience Inc.
Most cited
By later US patents
- RNA-guided human genome engineering263US 9,023,649 B2President and Fellows of Harvard College · 2015
- RNA-guided human genome engineering136US 9,260,723 B2President and Fellows of Harvard College · 2016
- Adenosine nucleobase editors and uses thereof114US 10,113,163 B2President and Fellows of Harvard College · 2018
- RNA-guided human genome engineering89US 9,970,024 B2President and Fellows of Harvard College · 2018
- Continuous directed evolution of proteins and nucleic acids73US 9,023,594 B2President and Fellows of Harvard College · 2015