C12N 15/102
Mutagenizing nucleic acids
Official title: {Mutagenizing nucleic acids}
C12N15/102 (Mutagenizing nucleic acids) appears on 2,197 US grants and 4,163 published applications in this corpus.
Search patents in C12N- Granted patents
- 2,197
- Published applications
- 4,163
- Assignees
- 1,225
- Inventors
- 6,007
- Latest grant
- 6 Oct 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1982 | 2 | 0 |
| 1983 | 0 | 0 |
| 1984 | 1 | 0 |
| 1985 | 2 | 0 |
| 1986 | 1 | 0 |
| 1987 | 3 | 0 |
| 1988 | 2 | 0 |
| 1989 | 3 | 0 |
| 1990 | 3 | 0 |
| 1991 | 4 | 0 |
| 1992 | 3 | 0 |
| 1993 | 8 | 0 |
| 1994 | 12 | 0 |
| 1995 | 9 | 0 |
| 1996 | 8 | 0 |
| 1997 | 15 | 0 |
| 1998 | 28 | 0 |
| 1999 | 31 | 0 |
| 2000 | 34 | 0 |
| 2001 | 50 | 6 |
| 2002 | 53 | 63 |
| 2003 | 45 | 110 |
| 2004 | 25 | 85 |
| 2005 | 21 | 70 |
| 2006 | 32 | 64 |
| 2007 | 28 | 40 |
| 2008 | 24 | 44 |
| 2009 | 19 | 41 |
| 2010 | 35 | 55 |
| 2011 | 26 | 43 |
| 2012 | 21 | 36 |
| 2013 | 30 | 46 |
| 2014 | 39 | 88 |
| 2015 | 34 | 103 |
| 2016 | 48 | 152 |
| 2017 | 71 | 158 |
| 2018 | 71 | 242 |
| 2019 | 126 | 333 |
| 2020 | 171 | 379 |
| 2021 | 164 | 361 |
| 2022 | 202 | 370 |
| 2023 | 196 | 403 |
| 2024 | 191 | 396 |
| 2025 | 200 | 275 |
| 2026 | 106 | 200 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Subgroups
Granted patents
Recent patents
- CRISPR-mediated directed codon re-write6 Oct 2026US 12,753,398 B2Limagrain Europe S.A.
- Modified nucleases22 Sep 2026US 12,742,163 B2Artisan Developments Labs, INC
- Altering tissue tropism of adeno-associated viruses15 Sep 2026US 12,735,725 B2Massachusetts Eye and Ear Infirmary
- S. pyogenes CAS9 mutant genes and polypeptides encoded by same1 Sep 2026US 12,723,264 B2Integrated Dna Technologies, Inc.
- Method for increasing mutation introduction efficiency in genome sequence modification technique, and molecular complex to be used therefor25 Aug 2026US 12,716,076 B2National University Corporation Kobe University
- Engineered compact crispr-cas12f system8 Oct 2026US 2026/0308554 A1
- Adenine base editors with reduced off-target effects8 Oct 2026US 2026/0308561 A1President and Fellows of Harvard College
- Methods of engineering cells with mutated genomes using intact large cargo transfer systems8 Oct 2026US 2026/0308568 A1
- Trems for use in correction of missense mutations1 Oct 2026US 2026/0294955 A1Flagship Pioneering Innovations VI, LLC
- Ribosomal Remodeling in Diabetes1 Oct 2026US 2026/0295074 A1Joslin Diabetes Center, Inc.
Most cited
By later US patents
- CRISPR-Cas systems and methods for altering expression of gene products1,186US 8,697,359 B1Massachusetts Institute of Technology · 2014
- Methods for in vitro recombination882US 5,605,793 AAffymax Technologies N.V. · 1997
- Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases880US 5,432,272 A1995
- Methods and compositions for cellular and metabolic engineering844US 5,837,458 AMaxygen, Inc. · 1998
- DNA mutagenesis by random fragmentation and reassembly791US 5,830,721 AAffymax Technologies N.V. · 1998