C12N 15/1031
Mutagenesis by gene assembly
Official title: {mutagenesis by gene assembly, e.g. assembly by oligonucleotide extension PCR}
C12N15/1031 (Mutagenesis by gene assembly) appears on 198 US grants and 328 published applications in this corpus.
Search patents in C12N- Granted patents
- 198
- Published applications
- 328
- Assignees
- 145
- Inventors
- 580
- Latest grant
- 11 Aug 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1995 | 1 | 0 |
| 1996 | 0 | 0 |
| 1997 | 0 | 0 |
| 1998 | 0 | 0 |
| 1999 | 0 | 0 |
| 2000 | 1 | 0 |
| 2001 | 4 | 1 |
| 2002 | 8 | 2 |
| 2003 | 7 | 12 |
| 2004 | 0 | 8 |
| 2005 | 2 | 7 |
| 2006 | 2 | 9 |
| 2007 | 3 | 5 |
| 2008 | 5 | 3 |
| 2009 | 5 | 9 |
| 2010 | 2 | 3 |
| 2011 | 3 | 9 |
| 2012 | 1 | 3 |
| 2013 | 3 | 7 |
| 2014 | 2 | 13 |
| 2015 | 8 | 18 |
| 2016 | 8 | 26 |
| 2017 | 12 | 19 |
| 2018 | 14 | 28 |
| 2019 | 14 | 18 |
| 2020 | 19 | 25 |
| 2021 | 14 | 25 |
| 2022 | 10 | 24 |
| 2023 | 12 | 16 |
| 2024 | 16 | 17 |
| 2025 | 10 | 14 |
| 2026 | 12 | 7 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- Intra-genomic homologous recombination11 Aug 2026US 12,703,869 B2Pioneer Hi-Bred International, Inc.
- Methods and compositions for enrichment of target polynucleotides28 Jul 2026US 12,692,539 B2Myriad Women's Health, Inc.
- Compositions and methods for multiplex nucleic acids synthesis30 Jun 2026US 12,668,791 B2Twist Bioscience Corporation
- Processes for the production of oligonucleotides9 Jun 2026US 12,649,939 B2GlaxoSmithKline Intellectual Property Development Limited
- In vitro rapid synthesis of medium- and high-copy DNA repeats based on blocking polymerase chain reaction2 Jun 2026US 12,644,114 B2Tsinghua University
- Ligation of oligonucleotides23 Jul 2026US 2026/0209813 A1Ribbon Bio GmbH
- Preparation of long read nucleic acid libraries18 Jun 2026US 2026/0167953 A1Illumina, Inc.
- Methods of Synthesizing Nucleic Acid Molecules14 May 2026US 2026/0132437 A1Telesis Bio Inc.
- High-throughput combinatorial genetic modification system and optimized cas9 enzyme variants23 Apr 2026US 2026/0109973 A1The University of Hong Kong
- Cloning and expression system for t-cell receptors5 Mar 2026US 2026/0062696 A1St. Jude Children?S Research Hospital
Most cited
By later US patents
- Oligonucleotide mediated nucleic acid recombination400US 6,376,246 B1Maxygen, Inc. · 2002
- Method for the complete chemical synthesis and assembly of genes and genomes364US 6,521,427 B1Egea Biosciences, Inc. · 2003
- Methods and compositions for polypeptide engineering338US 6,586,182 B1Maxygen, Inc. · 2003
- Oligonucloetide mediated nucleic acid recombination245US 6,521,453 B1Maxygen, Inc. · 2003
- Use of codon-varied oligonucleotide synthesis for synthetic shuffling234US 6,436,675 B1Maxygen, Inc. · 2002