C07K 2319/35
Containing a fusion for enhanced stability/folding during expression
Official title: containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
C07K2319/35 (Containing a fusion for enhanced stability/folding during expression) appears on 397 US grants and 558 published applications in this corpus.
Search patents in C07K- Granted patents
- 397
- Published applications
- 558
- Assignees
- 350
- Inventors
- 1,178
- Latest grant
- 21 Jul 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1987 | 1 | 0 |
| 1988 | 0 | 0 |
| 1989 | 2 | 0 |
| 1990 | 0 | 0 |
| 1991 | 2 | 0 |
| 1992 | 2 | 0 |
| 1993 | 4 | 0 |
| 1994 | 5 | 0 |
| 1995 | 0 | 0 |
| 1996 | 5 | 0 |
| 1997 | 8 | 0 |
| 1998 | 6 | 0 |
| 1999 | 5 | 0 |
| 2000 | 2 | 0 |
| 2001 | 6 | 1 |
| 2002 | 6 | 3 |
| 2003 | 3 | 9 |
| 2004 | 2 | 9 |
| 2005 | 6 | 14 |
| 2006 | 2 | 13 |
| 2007 | 7 | 18 |
| 2008 | 2 | 18 |
| 2009 | 15 | 25 |
| 2010 | 18 | 24 |
| 2011 | 13 | 25 |
| 2012 | 13 | 20 |
| 2013 | 20 | 18 |
| 2014 | 20 | 39 |
| 2015 | 20 | 33 |
| 2016 | 24 | 29 |
| 2017 | 24 | 28 |
| 2018 | 29 | 26 |
| 2019 | 17 | 30 |
| 2020 | 21 | 30 |
| 2021 | 21 | 29 |
| 2022 | 15 | 33 |
| 2023 | 13 | 23 |
| 2024 | 17 | 34 |
| 2025 | 12 | 17 |
| 2026 | 9 | 10 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- Interleukin-18 variants and methods of use21 Jul 2026US 12,685,759 B2Yale University
- Modified mini-nucleosome core proteins and use in nucleic acid delivery21 Apr 2026US 12,606,833 B2
- Interleukin-18 variants and methods of use7 Apr 2026US 12,594,325 B2Yale University
- Polypeptide tag and application thereof in in vitro protein synthesis7 Apr 2026US 12,595,283 B2Kangma-Healthcode (Shanghai) Biotech Co., Ltd.
- Modification of RNA-related enzymes for enhanced production17 Mar 2026US 12,577,600 B2Translate Bio, Inc.
- Il-22 fc fusion proteins and methods of use1 Oct 2026US 2026/0297150 A1Genentech, Inc.
- Engineered antibodies24 Sep 2026US 2026/0285948 A1Danisco US Inc.
- Transglutaminase substrates for labeling3 Sep 2026US 2026/0258075 A1Roche Diagnostics GmbH
- Temperature-sensitive cas9 protein30 Jul 2026US 2026/0218146 A1Novozymes A/S
- Tumor necrosis factor receptor agonistic mbs23 Jul 2026US 2026/0209370 A1Radiant Biotherapeutics Inc.
Most cited
By later US patents
- Expression and export technology of proteins as immunofusins276US 5,541,087 AFuji ImmunoPharmaceuticals Corporation · 1996
- Expression and export technology of proteins as immunofusins151US 5,726,044 AFuji ImmunoPharmaceuticals Corporation · 1998
- Methods and compositions for generating bioactive assemblies of increased complexity and uses128US 7,534,866 B2IBC Pharmaceuticals, Inc. · 2009
- Methods and compositions for generating bioactive assemblies of increased complexity and uses112US 7,906,121 B2IBC Pharmaceuticals, Inc. · 2011
- Fusion protein systems designed to increase soluble cytoplasmic expression of heterologous proteins in esherichia coli98US 5,989,868 AThe Board of Regents of the University of Oklahoma · 1999