Methods and compositions for generating bioactive assemblies of increased complexity and uses

A method of delivering a diagnostic or therapeutic agent comprising:

• a) obtaining a complex comprising,
• (i) an adaptor module selected from the group consisting of HSP70, α2 macroglobulin, HSA (human serum albumin), hP1 (human protamine 1), a heat shock protein, a human protamine and an Fc fragment of a human antibody;
• (ii) a first peptide and a second peptide, each peptide attached to the adaptor module and each peptide consisting of an AD moiety or a DDD moiety, wherein the AD moiety consisting of the peptide sequence from an anchoring domain of an AKAP (A-kinase anchoring protein) and the DDD moiety consisting of the peptide sequence from a dimerization and docking domain of protein kinase A RIα, RIβ, RIIα or RIIβ wherein the AD moiety consisting of peptide sequence selected from the group consisting of AD2 (SEQ ID NO:
• 2) and AD3 (SEQ ID NO:
• 5) and the DDD moiety consisting of the peptide sequence selected from the group consisting of DDD2 (SEQ ID NO:
• 1), DDD3 (SEQ ID NO:3) and DDD3C (SEQ ID NO:4);
• and
• (iii) at least one diagnostic agent or therapeutic agent attached to the first or second peptide;
• and
• b) administering the complex to a subject.