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US 2026/0209370 A1Published application
Tumor necrosis factor receptor agonistic mbs
AssigneeRadiant Biotherapeutics Inc.
InventorsJoanne Hulme, Peter Bayliss, Abilasha Rao
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Abstract
Fusion polypeptides comprising: (1) a TNF receptor-binding moiety and (2) a nanocage monomer or subunit thereof; self-assembled polypeptide complexes comprising such fusion polypeptides. Self-assembled polypeptide complexes comprising Fc fusion polypeptides and fusion polypeptides disclosed herein and/or tumor-binding fusion polypeptides, and related compositions and methods.
Claims54
A fusion polypeptide comprising:
- (1) a tumor necrosis factor (TNF) receptor-binding moiety and (2) a nanocage monomer or subunit thereof, wherein the TNF receptor-binding moiety is not capable of binding to death receptor 4 (DR4) or death receptor 5 (DR5).
Dependencies are inferred from the claim text.