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US 2026/0285948 A1Published application
Engineered antibodies
AssigneeDanisco US Inc.
InventorsJimmy CHAN, David A. ESTELL, Jeffrey Wayne MUNOS, Michael C. MILLER, Igor NIKOLAEV
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Abstract
Disclosed herein, inter alia, are cleavage-resistant antibodies and antibody-producing host cells as well as methods for making, using, and improving secretion of the same.
Claims21
A monoclonal IgG1 antibody heavy chain polypeptide comprising a hinge region that comprises one or more amino acid modification(s) that reduces proteolysis of the polypeptide.
21-45. (canceled)
Dependencies are inferred from the claim text.