C07K 16/468
Immunoglobulins having two or more different antigen binding sites
Official title: {Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies}
C07K16/468 (Immunoglobulins having two or more different antigen binding sites) appears on 1,277 US grants and 2,382 published applications in this corpus.
Search patents in C07K- Granted patents
- 1,277
- Published applications
- 2,382
- Assignees
- 623
- Inventors
- 3,618
- Latest grant
- 22 Sep 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1982 | 1 | 0 |
| 1983 | 0 | 0 |
| 1984 | 2 | 0 |
| 1985 | 0 | 0 |
| 1986 | 0 | 0 |
| 1987 | 2 | 0 |
| 1988 | 1 | 0 |
| 1989 | 1 | 0 |
| 1990 | 4 | 0 |
| 1991 | 2 | 0 |
| 1992 | 3 | 0 |
| 1993 | 5 | 0 |
| 1994 | 2 | 0 |
| 1995 | 3 | 0 |
| 1996 | 9 | 0 |
| 1997 | 13 | 0 |
| 1998 | 10 | 0 |
| 1999 | 19 | 0 |
| 2000 | 17 | 0 |
| 2001 | 22 | 4 |
| 2002 | 7 | 12 |
| 2003 | 11 | 10 |
| 2004 | 10 | 13 |
| 2005 | 5 | 20 |
| 2006 | 6 | 13 |
| 2007 | 1 | 19 |
| 2008 | 7 | 16 |
| 2009 | 8 | 38 |
| 2010 | 19 | 46 |
| 2011 | 13 | 42 |
| 2012 | 21 | 50 |
| 2013 | 27 | 126 |
| 2014 | 38 | 145 |
| 2015 | 50 | 108 |
| 2016 | 72 | 116 |
| 2017 | 88 | 155 |
| 2018 | 70 | 136 |
| 2019 | 79 | 190 |
| 2020 | 84 | 143 |
| 2021 | 99 | 139 |
| 2022 | 89 | 195 |
| 2023 | 89 | 222 |
| 2024 | 107 | 212 |
| 2025 | 102 | 127 |
| 2026 | 59 | 85 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- Binding molecules for the treatment of cancer22 Sep 2026US 12,742,022 B2Boehringer Ingelheim International GmbH
- Bispecific antigen binding molecules targeting OX40 and FAP15 Sep 2026US 12,735,485 B2Hoffmann-La Roche Inc.
- Multivalent protein complexes15 Sep 2026US 12,735,486 B2Guangzhou Binding Technologies Co., Limited
- Multi-domain CD1a antagonist/PD-1 agonist antibody molecules15 Sep 2026US 12,735,491 B2Immunocore Limited
- Bispecific anti-human a-beta/human transferrin receptor antibodies and methods of use15 Sep 2026US 12,735,497 B2Hoffmann-La Roche Inc.
- Multi-domain molecules8 Oct 2026US 2026/0308260 A1Immunocore Limited
- Il12rb2 binding molecules and methods of use8 Oct 2026US 2026/0308265 A1Synthekine, Inc.
- Anti-nme antibody and method of treating cancer or cancer metastasis8 Oct 2026US 2026/0308282 A1Minerva Biotechnologies Corporation
- Methods and means for the production of ig-like molecules8 Oct 2026US 2026/0308655 A1Merus N.V.
- Methods of producing multimeric proteins in eukaryotic host cells1 Oct 2026US 2026/0297125 A1Genentech, Inc.
Most cited
By later US patents
- Single polypeptide chain binding molecules2,454US 4,946,778 AGenex Corporation · 1990
- Production of chimeric antibodies - a combinatorial approach1,367US 5,565,332 ACambridge Antibody Technology Limited · 1996
- Target specific cross-linked heteroantibodies1,179US 4,676,980 AThe United States of America, as represented by the Secretary, Department of Health and Human Services · 1987
- Human monoclonal antibodies to programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics940US 8,008,449 B2Medarex, Inc. · 2011
- Method for making heteromultimeric polypeptides932US 5,731,168 AGenentech, Inc. · 1998