C07D 489/08
Oxygen atom
C07D489/08 (Oxygen atom) appears on 393 US grants and 445 published applications in this corpus.
Search patents in C07D- Granted patents
- 393
- Published applications
- 445
- Assignees
- 150
- Inventors
- 584
- Latest grant
- 30 Jun 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1978 | 2 | 0 |
| 1979 | 4 | 0 |
| 1980 | 3 | 0 |
| 1981 | 0 | 0 |
| 1982 | 2 | 0 |
| 1983 | 2 | 0 |
| 1984 | 5 | 0 |
| 1985 | 2 | 0 |
| 1986 | 1 | 0 |
| 1987 | 3 | 0 |
| 1988 | 4 | 0 |
| 1989 | 4 | 0 |
| 1990 | 1 | 0 |
| 1991 | 3 | 0 |
| 1992 | 1 | 0 |
| 1993 | 5 | 0 |
| 1994 | 3 | 0 |
| 1995 | 1 | 0 |
| 1996 | 0 | 0 |
| 1997 | 0 | 0 |
| 1998 | 3 | 0 |
| 1999 | 7 | 0 |
| 2000 | 3 | 0 |
| 2001 | 8 | 1 |
| 2002 | 3 | 3 |
| 2003 | 1 | 3 |
| 2004 | 2 | 6 |
| 2005 | 2 | 9 |
| 2006 | 3 | 9 |
| 2007 | 5 | 17 |
| 2008 | 2 | 20 |
| 2009 | 7 | 26 |
| 2010 | 13 | 30 |
| 2011 | 19 | 27 |
| 2012 | 26 | 27 |
| 2013 | 30 | 21 |
| 2014 | 31 | 25 |
| 2015 | 37 | 47 |
| 2016 | 24 | 46 |
| 2017 | 27 | 28 |
| 2018 | 23 | 19 |
| 2019 | 21 | 22 |
| 2020 | 13 | 20 |
| 2021 | 14 | 11 |
| 2022 | 8 | 8 |
| 2023 | 6 | 9 |
| 2024 | 2 | 4 |
| 2025 | 2 | 6 |
| 2026 | 5 | 1 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- Processes for preparing morphinan-6-one products with low levels of α, β-unsaturated ketone compounds30 Jun 2026US 12,667,564 B2SpecGX LLC
- Process for crystallizing nalmefene hydrochloride30 Jun 2026US 12,668,596 B2Rhodes Technologies
- Opioid receptor antagonists2 Jun 2026US 12,643,907 B2University of Southern California
- Process for the synthesis of noroxymorphone from morphine2 Jun 2026US 12,643,908 B2Navin Saxena Research & Technology Pvt. Ltd.
- Bivalent ligands to understand dimerization of the mu opioid receptor and the chemokine receptor CCR5 in neurological disorders2 Jun 2026US 12,643,909 B2Virginia Commonwealth University
- Solid state forms of dibuprenorphine ethyl ether and process for preparation thereof20 Aug 2026US 2026/0242386 A1Tapi Czech Industries S.R.O
- Analgesic delta opioid receptor bitopic ligands11 Dec 2025US 2025/0376477 A1University of Florida Research Foundation, Inc.
- Novel intermediate, method for preparing the same and application thereof16 Oct 2025US 2025/0320221 A1Sichuan University
- Method for preparing naldemedine24 Jul 2025US 2025/0236626 A1Yonsung Fine Chemical Co., Ltd.
- Naltrexamine derivatives bearing 5-member heterocyclic ring systems and opioid receptor modulators19 Jun 2025US 2025/0195504 A1Virginia Commonwealth University
Most cited
By later US patents
- Quaternary derivatives of noroxymorphone which relieve intestinal immobility186US 4,176,186 ABoehringer Ingelheim GmbH · 1979
- Method for controlling gastrointestinal dysmotility175US 4,987,136 AThe Rockefeller University · 1991
- Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone147US 7,683,072 B2Purdue Pharma L. P. · 2010
- Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone142US 7,674,799 B2Purdue Pharma L. P. · 2010
- Oxycodone hydrochloride having less than 25 PPM 14-hydroxycodeinone140US 7,674,800 B2Purdue Pharma L. P. · 2010