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US 2025/0195504 A1Published application
Naltrexamine derivatives bearing 5-member heterocyclic ring systems and opioid receptor modulators
AssigneeVirginia Commonwealth University
InventorYan ZHANG
Life of this patent
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Abstract
A series of non-peptide opioid receptor modulators having the general formula: (I) is provided. In the formula: R=(II) * is a chiral carbon; M is a saturated or unsaturated, branched or unbranched, substituted or unsubstituted alkyl chain from 0-10 atoms in length; X1, X2, X3, X4, or X5 are independently, C, N, O, or S; and R is attached to M by any of X1, X2, X3, X4, or X5. The compounds are used to treat disorders related to opioid receptor functions such as opioid addiction, opioid overdose, pain and constipation caused by opioid use.
Claims18
A compound having the general formula:
- where
- R=
- and is saturated, unsaturated, aromatic or heteroaromatic, where X1, X2, X3, X4 and X5 are independently C, N, O or S;
- M=a saturated or unsaturated, branched or unbranched, substituted or unsubstituted alkyl chain comprising from 0-10 carbon atoms;
- and
- * indicates a chiral C with an α or β configuration,
- and salts and stereoisomers thereof,
- wherein -M-R is not
5 more elements
Dependencies are inferred from the claim text.