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US 12,667,564 B2Granted
Processes for preparing morphinan-6-one products with low levels of α, β-unsaturated ketone compounds
AssigneeSpecGX LLC
InventorsHenry J. Buehler, William E. Dummitt, Anthony Mannino, Dennis C. Aubuchon, Hong Gu
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Abstract
The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of alpha, beta unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound.
Claims12
A process for preparing oxymorphone HCl having a reduced concentration of 14-hydroxymorphinone, comprising:
- a. forming a reaction mixture comprising oxymorphone HCl and 14-hydroxymorphinone;
- b. treating the reaction mixture with a non-thiol sulfur-containing compound to reduce the concentration of the 14-hydroxymorphinone in the reaction mixture;
- and
- c. recovering oxymorphone base to produce the oxymorphone HCl.
1 more element
Dependencies are inferred from the claim text.