Method for controlling gastrointestinal dysmotility
AssigneeThe Rockefeller University
InventorsMary J. Kreek, Jack Fishman
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Abstract
Method for controlling gastrointestinal dysmotility in humans by administration of opioid antagonists.
Claims24
A method for the relief of gastrointestinal dysmotility in a patient afflicted with an idiopathic gastrointestinal dysmotility which comprises administration of an amount which is effective to relieve said dysmotility of a compound represented by the formula:
- ##STR4## wherein R.sub.3 is 3'-methyl-2-buteneyl;
- allyl;
- cyclopropylmethyl;
- or cyclobutylmethyl and pharmaceutically acceptable salts thereof.
A method for the relief of gastrointestinal dysmotility in a patient afflicted with an idiopathic gastrointestinal dysmotility which comprises administration of an amount which is effective to relieve said dysmotility of a compound represented by the formula:
- ##STR5## wherein R is allyl or cyclopropylmethyl, R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydroxy or methoxy and pharmaceutically acceptable salts thereof.
A method for the relief of gastrointestinal dysmotility in a patient afflicted with an idiopathic gastrointestinal dysmotility which comprises administration of an amount which is effective to relieve said dysmotility of a compound represented by the formula:
- ##STR6## and the corresponding dehydro compounds wherein R.sub.4 is methoxy or hydroxy, R.sub.5 is hydrogen or hydroxy, and R.sub.6 is hydrogen, methyl, ethyl, propyl, allyl and benzyl, and the pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.