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US 12,668,596 B2Granted
Process for crystallizing nalmefene hydrochloride
AssigneeRhodes Technologies
InventorC. Frederick M. Huntley
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Abstract
The application is directed to an efficient process for crystallizing nalmefene hydrochloride in a hydrated form from an aqueous hydrochloric acid solution (or a mixture) with a high yield.
Claims20
A process for crystallizing nalmefene hydrochloride, said process comprising:
- mixing a source of nalmefene, water and hydrochloric acid to provide a substantially homogeneous mixture, wherein the hydrochloric acid is present in said substantially homogeneous mixture in an amount sufficient to achieve a final molarity of about 3 M to about 4 M;
- and
- crystallizing said nalmefene hydrochloride from said substantially homogeneous mixture to provide a heterogenous mixture comprising crystalline hydrated form of nalmefene hydrochloride in an acidic aqueous continuous phase.
Dependencies are inferred from the claim text.