C12P 37/00
Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system
Official title: Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
C12P37/00 (Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system) appears on 113 US grants and 67 published applications in this corpus.
Search patents in C12P- Granted patents
- 113
- Published applications
- 67
- Assignees
- 66
- Inventors
- 343
- Latest grant
- 18 Nov 2025
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1977 | 2 | 0 |
| 1978 | 2 | 0 |
| 1979 | 1 | 0 |
| 1980 | 1 | 0 |
| 1981 | 4 | 0 |
| 1982 | 4 | 0 |
| 1983 | 3 | 0 |
| 1984 | 2 | 0 |
| 1985 | 3 | 0 |
| 1986 | 3 | 0 |
| 1987 | 4 | 0 |
| 1988 | 3 | 0 |
| 1989 | 1 | 0 |
| 1990 | 1 | 0 |
| 1991 | 1 | 0 |
| 1992 | 2 | 0 |
| 1993 | 2 | 0 |
| 1994 | 2 | 0 |
| 1995 | 2 | 0 |
| 1996 | 4 | 0 |
| 1997 | 3 | 0 |
| 1998 | 3 | 0 |
| 1999 | 6 | 0 |
| 2000 | 7 | 0 |
| 2001 | 6 | 0 |
| 2002 | 3 | 7 |
| 2003 | 2 | 5 |
| 2004 | 1 | 5 |
| 2005 | 2 | 1 |
| 2006 | 3 | 6 |
| 2007 | 3 | 2 |
| 2008 | 2 | 4 |
| 2009 | 0 | 3 |
| 2010 | 1 | 2 |
| 2011 | 0 | 4 |
| 2012 | 1 | 1 |
| 2013 | 3 | 0 |
| 2014 | 2 | 5 |
| 2015 | 2 | 1 |
| 2016 | 2 | 6 |
| 2017 | 4 | 3 |
| 2018 | 2 | 1 |
| 2019 | 0 | 3 |
| 2020 | 1 | 1 |
| 2021 | 2 | 1 |
| 2022 | 1 | 1 |
| 2023 | 1 | 0 |
| 2024 | 0 | 2 |
| 2025 | 3 | 1 |
| 2026 | 0 | 2 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Subgroups
Granted patents
- C12P 37/04Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system: by acylation27
- C12P 37/06Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system: by desacylation22
- C12P 37/02In presence of phenylacetic acid or phenylacetamide or their derivatives not to1
Recent patents
- One-step method for synthesizing amoxicillin from penicillin or salt thereof through enzyme catalysis18 Nov 2025US 12,473,580 B1Xingzhi College Zhejiang Normal University
- Method for separating amoxicillin and phenylacetic acid from reaction solution in one-step enzymatic synthesis of amoxicillin2 Sep 2025US 12,404,534 B1Xingzhi College Zhejiang Normal University
- Monooxygenase mutant and use thereof28 Jan 2025US 12,209,258 B2Asymchem Life Science (Tianjin) Co., Ltd
- Glucoamylase variants and polynucleotides encoding same12 Dec 2023US 11,840,713 B2Novozymes A/S
- Enzyme-immobilized porous membrane and preparation method of antibiotics using the same14 Jun 2022US 11,359,224 B2Gwangju Institute of Science and Technology
- Biosynthesis of beta-lactam antibiotics24 Sep 2026US 2026/0286334 A1
- Mutant penicillin acylase and uses thereof30 Apr 2026US 2026/0117216 A1Xingzhi College Zhejiang Normal University
- Glucoamylase variants and polynucleotides encoding same24 Jul 2025US 2025/0236859 A1Novozymes A/S
- Protein-based material for biocatalysis11 Apr 2024US 2024/0116992 A1Bondwell Technologies LP
- Glucoamylase variants and polynucleotides encoding same14 Mar 2024US 2024/0084277 A1Novozymes A/S
Most cited
By later US patents
- Mutated penicillin G acylase genes42US 5,891,703 AGist-Hrocades · 1999
- Immobilized cells for preparing phenylalanine39US 4,600,692 APurification Engineering, Inc. · 1986
- Mutated penicillin G acylase genes38US 6,033,823 A2000
- Immobilization of biological material with an acrylonitrile polymer36US 4,371,612 AToyo Jozo Kabushiki Kaisha · 1983
- Modulation of secondary metabolite production by zinc binuclear cluster proteins30US 7,229,784 B2Microbia, Inc. · 2007