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US 7,229,784 B2Granted
Modulation of secondary metabolite production by zinc binuclear cluster proteins
AssigneeMicrobia, Inc.
InventorsDouglas Holtzman, Kevin T. Madden, Mary Maxon, Amir Sherman
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Abstract
Methods for improving the production of a secondary metabolite by a fungus by increasing the yield or productivity of the secondary metabolite produced by the fungus are described. The methods include increasing the expression of LYS14, for example, by transforming a cell with a nucleic acid molecule encoding LYS14.
Claims42
A method for improving the production of a secondary metabolite by a fungus by increasing the yield or productivity of the secondary metabolite produced by the fungus, the method comprising:
- increasing the expression of a gene encoding a protein comprising the amino acid sequence encoded by SEQ ID NO:157 in a manner that improves the yield or productivity of the secondary metabolite.
A method for producing a secondary metabolite, the method comprising:
- a) providing a fungal cell transformed with a nucleic acid molecule encoding a protein comprising the amino acid sequence encoded by SEQ ID NO:157;
- b) culturing the fungal cell under conditions suitable for production of the secondary metabolite;
- and
- c) isolating a fraction containing the secondary metabolite from the medium in which the fungal cell has been cultured or from the fungal cell.
1 more element
Dependencies are inferred from the claim text.