C12N 9/6454
Dibasic site splicing serine proteases
Official title: {Dibasic site splicing serine proteases, e.g. kexin (3.4.21.61); furin (3.4.21.75) and other proprotein convertases}
C12N9/6454 (Dibasic site splicing serine proteases) appears on 104 US grants and 115 published applications in this corpus.
Search patents in C12N- Granted patents
- 104
- Published applications
- 115
- Assignees
- 89
- Inventors
- 328
- Latest grant
- 3 Jun 2025
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1995 | 2 | 0 |
| 1996 | 1 | 0 |
| 1997 | 2 | 0 |
| 1998 | 9 | 0 |
| 1999 | 9 | 0 |
| 2000 | 5 | 0 |
| 2001 | 5 | 0 |
| 2002 | 2 | 0 |
| 2003 | 2 | 4 |
| 2004 | 1 | 2 |
| 2005 | 0 | 1 |
| 2006 | 2 | 0 |
| 2007 | 0 | 3 |
| 2008 | 0 | 2 |
| 2009 | 3 | 6 |
| 2010 | 1 | 1 |
| 2011 | 2 | 5 |
| 2012 | 3 | 5 |
| 2013 | 3 | 5 |
| 2014 | 3 | 4 |
| 2015 | 3 | 7 |
| 2016 | 4 | 4 |
| 2017 | 4 | 8 |
| 2018 | 7 | 7 |
| 2019 | 1 | 8 |
| 2020 | 4 | 4 |
| 2021 | 8 | 8 |
| 2022 | 5 | 6 |
| 2023 | 3 | 8 |
| 2024 | 5 | 8 |
| 2025 | 5 | 7 |
| 2026 | 0 | 2 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- Methods to spatially profile protease activity in tissue and sections3 Jun 2025US 12,320,801 B2Massachusetts Institute of Technology
- Multispecific antigen-binding molecules and uses thereof13 May 2025US 12,297,257 B2Regeneron Pharmaceuticals, Inc.
- Modified activin A6 May 2025US 12,291,554 B2Mitsubishi Chemical Corporation
- Bioactive plastics with programmable degradation and microplastic elimination22 Apr 2025US 12,281,208 B2The Regents of the University of California
- PCSK9 antagonist compounds28 Jan 2025US 12,209,145 B2Merck Sharp & Dohme Corp.
- Vector production24 Sep 2026US 2026/0286391 A1Fondazione Telethon Ets
- Compositions and methods for the targeting of pcsk920 Aug 2026US 2026/0241032 A1Scribe Therapeutics Inc.
- Compositions, systems, and methods for treating familial hypercholesterolemia by targeting pcsk925 Dec 2025US 2025/0388885 A1Epicrispr Biotechnologies, Inc.
- Variant Preproinsulin and Constructs for Insulin Expression and Treatment of Diabetes2 Oct 2025US 2025/0304648 A1Endsulin, Inc.
- Pcsk9 endonuclease variants, compositions, and methods of use21 Aug 2025US 2025/0262323 A1Novo Nordisk A/S
Most cited
By later US patents
- Expression of PACE in host cells and methods of use thereof177US 5,460,950 AChiron Corporation · 1995
- Methods for increasing efficacy of lipid formulated siRNA103US 9,051,567 B2Tekmira Pharmaceuticals Corporation · 2015
- Yeast-based delivery vehicles89US 5,830,463 AUniversity Technology Corporation · 1998
- P-selectin ligand protein80US 5,827,817 AGenetics Institute, Inc. · 1998
- Yeast assay to identify inhibitors of dibasic amino acid processing endoproteases78US 5,413,914 AThe Regents of the University of Colorado · 1995