P-selectin ligand protein
AssigneeGenetics Institute, Inc.
InventorsGlenn R. Larsen, Dianne S. Sako, Xiao-Jia Chang, Geertruida M. Veldman, Dale Cumming, Ravindra Kumar, Gray Shaw, Ray Camphausen
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Abstract
A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
Claims16
An isolated glycoprotein having P-selectin ligand activity comprising a carbohydrate and a protein comprising the sequence from amino acid 42 to amino acid 60 of SEQ ID NO:
- 2, wherein said carbohydrate comprises sLe.sup.X, and wherein said isolated glycoprotein does not comprise the transmembrane domain and the intracellular domain of mature P-selectin ligand protein or does not comprise the intracellular domain of mature P-selectin ligand protein.
Dependencies are inferred from the claim text.