C07D 489/12
The bridge containing only two carbon atoms
Official title: the bridge containing only two carbon atoms
C07D489/12 (The bridge containing only two carbon atoms) appears on 92 US grants and 120 published applications in this corpus.
Search patents in C07D- Granted patents
- 92
- Published applications
- 120
- Assignees
- 41
- Inventors
- 191
- Latest grant
- 13 Jan 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1976 | 3 | 0 |
| 1977 | 1 | 0 |
| 1978 | 0 | 0 |
| 1979 | 0 | 0 |
| 1980 | 0 | 0 |
| 1981 | 0 | 0 |
| 1982 | 0 | 0 |
| 1983 | 0 | 0 |
| 1984 | 0 | 0 |
| 1985 | 0 | 0 |
| 1986 | 0 | 0 |
| 1987 | 0 | 0 |
| 1988 | 0 | 0 |
| 1989 | 0 | 0 |
| 1990 | 0 | 0 |
| 1991 | 0 | 0 |
| 1992 | 0 | 0 |
| 1993 | 0 | 0 |
| 1994 | 0 | 0 |
| 1995 | 0 | 0 |
| 1996 | 0 | 0 |
| 1997 | 0 | 0 |
| 1998 | 1 | 0 |
| 1999 | 0 | 0 |
| 2000 | 1 | 0 |
| 2001 | 2 | 0 |
| 2002 | 2 | 2 |
| 2003 | 0 | 1 |
| 2004 | 3 | 5 |
| 2005 | 1 | 5 |
| 2006 | 3 | 1 |
| 2007 | 3 | 1 |
| 2008 | 0 | 2 |
| 2009 | 1 | 7 |
| 2010 | 0 | 10 |
| 2011 | 5 | 10 |
| 2012 | 8 | 5 |
| 2013 | 4 | 2 |
| 2014 | 4 | 10 |
| 2015 | 10 | 10 |
| 2016 | 10 | 12 |
| 2017 | 7 | 10 |
| 2018 | 6 | 6 |
| 2019 | 6 | 3 |
| 2020 | 4 | 2 |
| 2021 | 2 | 5 |
| 2022 | 2 | 0 |
| 2023 | 1 | 2 |
| 2024 | 1 | 1 |
| 2025 | 0 | 2 |
| 2026 | 1 | 6 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- Long-acting injectable formulations and crystalline forms of buprenorphine derivatives13 Jan 2026US 12,522,610 B2Alar Pharmaceuticals Inc.
- Process for the synthesis of buprenorphine20 Feb 2024US 11,905,296 B2Azad Pharma AG
- Lymph directing prodrugs29 Aug 2023US 11,738,087 B2Monash University
- Long-acting injectable formulations and crystalline forms of buprenorphine derivatives13 Dec 2022US 11,524,965 B2Alar Pharmaceuticals Inc.
- Preparation of buprenorphine19 Jul 2022US 11,390,628 B2River Stone Biotech, LLC
- Solid state forms of dibuprenorphine ethyl ether and process for preparation thereof20 Aug 2026US 2026/0242386 A1Tapi Czech Industries S.R.O
- Process for Synthesizing Opioid Derivatives20 Aug 2026US 2026/0242387 A1Euroapi Hungary, LLC
- Long-acting injectable formulations and crystalline forms of buprenorphine derivatives6 Aug 2026US 2026/0226072 A1Alar Pharmaceuticals Inc.
- Improved synthesis of buprenorphine, analogues and intermediates30 Jul 2026US 2026/0217726 A1
- Lymph directing prodrugs4 Jun 2026US 2026/0151489 A1Monash University
Most cited
By later US patents
- Methods of using 8-carboxamido-2,6-methano-3-benzazocines58US 8,642,615 B2Rensselaer Polytechnic Institute · 2014
- 8-carboxamido-2,6-methano-3-benzazocines38US 6,784,187 B2Rensselaer Polytechnic Inst. · 2004
- Methods of o-demethylation and n-deprotection37US 6,291,675 B1The United States as represented by the Department of Health and Human Services · 2001
- Production of thebaine and oripavine36US 6,723,894 B2Tasmanian Alkaloids Pty. Ltd. · 2004
- 1-alkyl-4-(3-substitutedphenyl)piperidines32US 7,265,226 B2Rensselaer Polytechnic Institute · 2007