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US 7,265,226 B2Granted
1-alkyl-4-(3-substitutedphenyl)piperidines
AssigneeRensselaer Polytechnic Institute
InventorMark P. Wentland
Life of this patent
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Abstract
8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is —CH2—OH, —CH2NH2, —NHSO2CH3, and Y is O, S or NOH are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. 8-Carboxamides, thiocarboxamides, hydroxyamidines and formamides are preferred.
Claims12
A compound of formula
- wherein
- A is chosen from the group consisting of:
- —CONH2, —C(═S)NH2, —C(O)NHOH, and —NHCHO;
- and
- R is chosen from the group consisting of —CH3, —CH2CH2CH(OH)C6H11, —CH2CH(CH2Ph)CONHCH2CO2H, —(CH2)3CH(CH3)2 and —(CH2) 3-2-thienyl.
2 more elements
Dependencies are inferred from the claim text.