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US 11,738,087 B2Granted
Lymph directing prodrugs
AssigneeMonash University
InventorsChris Porter, Jamie Simpson, Natalie Trevaskis, Tim Quach, Sifei Han, Luojuan Hu
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that pro mote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.
Claims26
A compound of the formula (I):
- wherein
- R1 and R2 independently represent H, or a residue of a C2-C28 fatty acid;
- —X— is selected from —O—, —NH— and —S—;
- represents a pharmaceutical agent;
- -L- is —X′—;
- —Y— represents an optionally substituted —C1-C2alkylC(O)R3— group or a —C2alkenylC(O)R3— or —C2alkynylC(O)R3— group;
- R3 is a self-immolative group;
- X′ is O, S, N(R4) or N(H)S(O)2;
- and
- R4 is H or C1-C4alkyl;
- or,
- pharmaceutically acceptable salts thereof.
9 more elements
A compound of the formula (I):
- wherein
- R1 and R2 independently represent H, or a residue of a C2-C28 fatty acid;
- —X— is —O—;
- represents a pharmaceutical agent;
- -L- is —X′—;
- —Y— represents an optionally substituted —C1-C2alkylC(O)R3— group or a —C2alkenylC(O)R3— or —C2alkynylC(O)R3— group;
- R3 is a self-immolative group;
- and
- X′ is O;
- or
- pharmaceutically acceptable salts thereof.
8 more elements
Dependencies are inferred from the claim text.