Methods of using 8-carboxamido-2,6-methano-3-benzazocines
AssigneeRensselaer Polytechnic Institute
InventorMark P. Wentland
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Abstract
8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is —CH2—OH, —CH2NH2, —NHSO2CH3, and Y is O, S or NOH are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. 8-Carboxamides, thiocarboxamides, hydroxyamidines and formamides are preferred.
Claims17
A method of treating a disease or condition selected from pain, pruritus, diarrhea, cough, drug addiction, and irritable bowel syndrome comprising the step of administering to a subject in need thereof a compound of formula:
- wherein
- A is
- Y is chosen from O and S;
- R1 is —NHR8;
- R2 and R2a are both hydrogen or taken together R2 and R2a are ═O;
- R3 is chosen from hydrogen, lower alkyl, alkenyl, aryl, heterocyclyl, benzyl and hydroxyalkyl;
- R4 is chosen from hydrogen, hydroxy, amino, lower alkoxy, C1-C20 alkyl and C1-C20 alkyl substituted with hydroxy or carbonyl;
- R5 is lower alkyl;
- R6 is lower alkyl;
- R7 is chosen from hydrogen and hydroxy;
- or together R4, R5, R6 and R7 may form from one to three rings, said rings having optional additional substitution;
- and,
- R8 is hydrogen.
A method of treating a disease or condition selected from pain, pruritus, diarrhea, cough, drug addiction, and irritable bowel syndrome, comprising the step of administering a 3-carboxamide substituted morphinan compound to a subject in need thereof.
Dependencies are inferred from the claim text.