A61K 48/0066
Manipulation of the nucleic acid to modify its expression pattern
Official title: {Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid}
A61K48/0066 (Manipulation of the nucleic acid to modify its expression pattern) appears on 623 US grants and 1,564 published applications in this corpus.
Search patents in A61K- Granted patents
- 623
- Published applications
- 1,564
- Assignees
- 579
- Inventors
- 2,481
- Latest grant
- 6 Oct 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1998 | 1 | 0 |
| 1999 | 1 | 0 |
| 2000 | 1 | 0 |
| 2001 | 1 | 0 |
| 2002 | 0 | 8 |
| 2003 | 3 | 5 |
| 2004 | 2 | 8 |
| 2005 | 1 | 6 |
| 2006 | 2 | 14 |
| 2007 | 2 | 11 |
| 2008 | 2 | 3 |
| 2009 | 3 | 15 |
| 2010 | 1 | 12 |
| 2011 | 6 | 15 |
| 2012 | 10 | 15 |
| 2013 | 8 | 40 |
| 2014 | 12 | 49 |
| 2015 | 26 | 52 |
| 2016 | 33 | 78 |
| 2017 | 25 | 61 |
| 2018 | 25 | 119 |
| 2019 | 51 | 158 |
| 2020 | 52 | 103 |
| 2021 | 63 | 104 |
| 2022 | 61 | 134 |
| 2023 | 65 | 172 |
| 2024 | 59 | 156 |
| 2025 | 66 | 133 |
| 2026 | 41 | 93 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- Methods and materials for ameliorating creatine deficiency disorders6 Oct 2026US 12,751,995 B2The Regents of the University of California
- Compositions and methods for the treatment of hemophilia6 Oct 2026US 12,753,418 B2Poseida Therapeutics, Inc.
- Method for modulating RNA splicing by inducing base mutation at splice site or base substitution in polypyrimidine region6 Oct 2026US 12,753,420 B2Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- DCAS13-mediated therapeutic RNA base editing for in vivo gene therapy29 Sep 2026US 12,746,295 B2University of Massachusetts
- RNA encoding an antibody29 Sep 2026US 12,747,451 B2Cure Vac SE
- Nucleic acids encoding crispr-associated proteins and uses thereof8 Oct 2026US 2026/0308602 A1CureVac AG
- Expression cassette coding for vascular endothelial growth factor8 Oct 2026US 2026/0308618 A1Cornell University
- Composition and methods for modulation of elovl224 Sep 2026US 2026/0284154 A1The Regents of the University of California
- Methods and system for optogenetic stimulation of adipocytes24 Sep 2026US 2026/0284229 A1MaineHealth
- Polynucleotide molecule comprising poly(a) and use thereof24 Sep 2026US 2026/0286369 A1Shenzhen Shenxin Biotechnology Co., Ltd.
Most cited
By later US patents
- Engineered nucleic acids and methods of use thereof372US 8,822,663 B2Moderna Therapeutics, Inc. · 2014
- RNA containing modified nucleosides and methods of use thereof353US 8,278,036 B2The Trustees of the University of Pennsylvania · 2012
- RNA containing modified nucleosides and methods of use thereof230US 8,691,966 B2The Trustees of the University of Pennsylvania · 2014
- RNA containing modified nucleosides and methods of use thereof222US 8,748,089 B2The Trustees of the University of Pennsylvania · 2014
- RNA containing modified nucleosides and methods of use thereof198US 8,835,108 B2The Trustees of the University of Pennsylvania · 2014