Back to results
US 8,822,663 B2Granted
Engineered nucleic acids and methods of use thereof
AssigneeModerna Therapeutics, Inc.
InventorsJason P. Schrum, Stéphane Bancel, Noubar B. Afeyan
Life of this patent
Estimating the term…
Abstract
Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing.
Claims4
A pharmaceutical formulation comprising:
- i) an effective amount of a mRNA sequence encoding a granulocyte colony-stimulating factor (G-CSF) polypeptide wherein the mRNA sequence is at least 95% identical to the sequence of SEQ ID NO:
- 17;
- and
- ii) a pharmaceutically acceptable carrier, wherein the formulation is suitable for repeated intravenous administration to a mammalian subject in need thereof.
1 more element
A pharmaceutical formulation consisting essentially of:
- i) an effective amount of a mRNA sequence encoding a granulocyte colony-stimulating factor (G-CSF) polypeptide wherein the mRNA sequence is at least 95% identical to the sequence of SEQ ID NO:
- 17;
- ii) a cell penetration agent;
- and
- iii) a pharmaceutically acceptable carrier, wherein the formulation is suitable for repeated intravenous administration to a mammalian subject in need thereof.
2 more elements
Dependencies are inferred from the claim text.