RNA encoding an antibody
AssigneeCure Vac SE
InventorsMariola Fotin-Mleczek, Ingmar Hoerr
Life of this patent
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Abstract
The present invention relates to a RNA encoding an antibody or a fragment or variant thereof and a composition, in particular a passive vaccine, comprising such an RNA. The present invention further relates to the use of such an RNA or of such a composition for treatment of tumours and cancer diseases, cardiovascular diseases, infectious diseases, autoimmune diseases, virus diseases and monogenetic diseases, e.g. also in gene therapy. The present invention also relates to a combination of at least two modified RNA's, in particular wherein one RNA encodes a heavy chain variable region of an antibody and another RNA encodes the corresponding light chain variable region of said antibody.
Claims16
A composition comprising:
- (I) an RNA comprising
- (a) at least a first coding sequence, wherein the first coding sequence comprises a nucleic acid sequence at least 90% identical to the RNA sequence of SEQ ID NO:
- 8323 and encoding a polypeptide according to SEQ ID NO:
- 681;
- and
- (b) at least a second coding sequence, wherein the second coding sequence comprises a nucleic acid sequence at least 90% identical to the RNA sequence of SEQ ID NO:
- 8324 and encoding a polypeptide according to SEQ ID NO:
- 682, wherein the first coding sequence and the second coding sequence are present in the same RNA molecule;
- or
- (II)
- (a) at least a first RNA molecule comprising at least a first coding sequence, wherein the first coding sequence comprises a nucleic acid sequence at least 90% identical to the RNA sequence of SEQ ID NO:
- 8323 and encoding a polypeptide according to SEQ ID NO:
- 681;
- and
- (b) at least a second RNA molecule comprising at least a second coding sequence, wherein the second coding sequence comprises a nucleic acid sequence at least 90% identical to the RNA sequence of SEQ ID NO:
- 8324 and encoding a polypeptide according to SEQ ID NO:
- 682.
Dependencies are inferred from the claim text.