A61K 41/0028
Disruption
Official title: {Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds}
A61K41/0028 (Disruption) appears on 537 US grants and 916 published applications in this corpus.
Search patents in A61K- Granted patents
- 537
- Published applications
- 916
- Assignees
- 437
- Inventors
- 1,671
- Latest grant
- 6 Oct 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1976 | 1 | 0 |
| 1977 | 0 | 0 |
| 1978 | 0 | 0 |
| 1979 | 0 | 0 |
| 1980 | 0 | 0 |
| 1981 | 0 | 0 |
| 1982 | 0 | 0 |
| 1983 | 0 | 0 |
| 1984 | 1 | 0 |
| 1985 | 0 | 0 |
| 1986 | 0 | 0 |
| 1987 | 0 | 0 |
| 1988 | 1 | 0 |
| 1989 | 1 | 0 |
| 1990 | 4 | 0 |
| 1991 | 0 | 0 |
| 1992 | 1 | 0 |
| 1993 | 5 | 0 |
| 1994 | 5 | 0 |
| 1995 | 2 | 0 |
| 1996 | 5 | 0 |
| 1997 | 2 | 0 |
| 1998 | 15 | 0 |
| 1999 | 7 | 0 |
| 2000 | 16 | 0 |
| 2001 | 21 | 13 |
| 2002 | 14 | 17 |
| 2003 | 17 | 23 |
| 2004 | 14 | 21 |
| 2005 | 3 | 24 |
| 2006 | 8 | 14 |
| 2007 | 5 | 27 |
| 2008 | 5 | 28 |
| 2009 | 10 | 20 |
| 2010 | 7 | 25 |
| 2011 | 7 | 38 |
| 2012 | 9 | 22 |
| 2013 | 12 | 37 |
| 2014 | 11 | 23 |
| 2015 | 17 | 40 |
| 2016 | 18 | 41 |
| 2017 | 24 | 34 |
| 2018 | 23 | 42 |
| 2019 | 32 | 54 |
| 2020 | 33 | 65 |
| 2021 | 38 | 61 |
| 2022 | 30 | 65 |
| 2023 | 27 | 63 |
| 2024 | 41 | 58 |
| 2025 | 21 | 31 |
| 2026 | 24 | 30 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Subgroups
Granted patents
Recent patents
- Compositions and methods for laser lithotripsy using nanoparticle fine-tuned NIR absorption6 Oct 2026US 12,751,766 B2Duke University
- Methods of producing microbubble drug conjugates, viral gene therapy microbubble conjugates and targeted microbubbles29 Sep 2026US 12,746,292 B2
- Methods of using ultrasound waves for sonodynamic therapy22 Sep 2026US 12,741,161 B2Alpheus Medical, Inc.
- Cancer treatment methods using thermotherapy and/or enhanced immunotherapy15 Sep 2026US 12,734,238 B2
- Method and system for applying pulsed electric fields with high uniformity using charged ring structures1 Sep 2026US 12,721,894 B2The Phantom Laboratory, Incorporated
- Fusion proteins of il-24 and immunostimulatory cytokines, nk cells expressing il-24 or fusion proteins, and methods of use thereof8 Oct 2026US 2026/0308218 A1Virginia Commonwealth University
- Systems and methods for targeted breast cancer therapies1 Oct 2026US 2026/0294809 A1American University of Sharjah
- Compositions comprising water and ultrafine bubbles and methods of using thereof in industrial and manufacturing processes1 Oct 2026US 2026/0295045 A1Hydrosome IP, LLC
- Sonosensitization1 Oct 2026US 2026/0295046 A1SonalaSense, Inc.
- Targeting Microbubbles17 Sep 2026US 2026/0273061 A1California Institute of Technology
Most cited
By later US patents
- Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously662US 5,558,092 AImaRx Pharmaceutical Corp. · 1996
- Therapeutic drug delivery systems498US 5,580,575 AImaRx Pharmaceutical Corp. · 1996
- Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles426US 5,733,572 AImaRx Pharmaceutical Corp. · 1998
- Therapeutic delivery systems related applications384US 5,542,935 AImaR.sub.x Pharmaceutical Corp. · 1996
- Methods of preparing gas-filled liposomes362US 5,469,854 AImaR.sub.x Pharmaceutical Corp. · 1995