Cancer treatment methods using thermotherapy and/or enhanced immunotherapy
OwnerGholam A. Peymaninventor
Life of this patent
Estimating the term…
Abstract
Cancer treatment methods using thermotherapy and/or enhanced immunotherapy are disclosed herein. In one embodiment, the method comprising the steps of: (i) applying controlled thermal energy at 40-43° C. for a first predetermined time period to damage and weaken tumor cells of a tumor in a patient; (ii) administering pulsed high intensity focused ultrasound (pHIFU) in a first ultrasound mode to the tumor cells in the patient so as to damage the tumor cells without increasing the thermal energy; and (iii) administering low intensity focused ultrasound (LIFU) in a second ultrasound mode to further damage the tumor cells at a temperature of 39-43° C. for a second predetermined time period while performing observation of the tumor cells by ultrasonic thermometry.
Claims11
A cancer treatment and imaging method comprising the steps of:
- systemically administering antibody-coated piezoelectric nanoparticles to a patient in need thereof so as to target a tumor in the patient, the piezoelectric nanoparticles being further coated with a biocompatible polymer, and a medication being conjugated with the biocompatible polymer coating of the piezoelectric nanoparticles, the piezoelectric nanoparticles attaching to surface antigens of tumor cells of the tumor so as to accumulate at a site of the tumor and form a tumor cell/nanoparticle complex;
- applying a pulsed electrical current to the piezoelectric nanoparticles using an electrical source at the site of the tumor so as to create an electroacoustic sound from the piezoelectric nanoparticles, the electrical source comprising a power generation device with an anode located on a first side of the skin of the body of the patient and a cathode being located on a second side of the skin of the body of the patient, the anode being located on a first side of the tumor and the cathode being located on a second side of the tumor, and the piezoelectric nanoparticles accumulated at the site of the tumor generating the electroacoustic sound in response to the pulsed electrical current applied to the piezoelectric nanoparticles, the pulsed electrical current passing through the tumor in the body of the patient from the first side of the tumor to the second side of the tumor;
- recording the electroacoustic sound generated by the piezoelectric nanoparticles using a transducer to convert the electroacoustic sound to an electrical signal;
- and
- amplifying and transmitting the electrical signal to a processor so that a 1-dimensional, 2-dimensional, or 3-dimensional image of the tumor structure is able to be generated in the form of an electroacoustic computed tomogram.
A cancer treatment and imaging method comprising the steps of:
- systemically administering antibody-coated pyroelectric nanoparticles to a patient in need thereof so as to target a tumor in the patient, the pyroelectric nanoparticles being further coated with a biocompatible polymer, and a medication being conjugated with the biocompatible polymer coating of the pyroelectric nanoparticles, the pyroelectric nanoparticles attaching to surface antigens of tumor cells of the tumor so as to accumulate at a site of the tumor and form a tumor cell/nanoparticle complex;
- applying a pulsed electrical current to the pyroelectric nanoparticles using an electrical source at the site of the tumor so as to create an electroacoustic sound from the pyroelectric nanoparticles, the electrical source comprising a power generation device with an anode located on a first side of the skin of the body of the patient and a cathode being located on a second side of the skin of the body of the patient, the anode being located on a first side of the tumor and the cathode being located on a second side of the tumor, and the pyroelectric nanoparticles accumulated at the site of the tumor generating the electroacoustic sound in response to the pulsed electrical current applied to the pyroelectric nanoparticles, the pulsed electrical current passing through the tumor in the body of the patient from the first side of the tumor to the second side of the tumor;
- recording the electroacoustic sound generated by the pyroelectric nanoparticles using a transducer to convert the electroacoustic sound to an electrical signal;
- and
- amplifying and transmitting the electrical signal to a processor so that a 1-dimensional, 2-dimensional, or 3-dimensional image of the tumor structure is able to be generated in the form of an electroacoustic computed tomogram.
Dependencies are inferred from the claim text.