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US 2026/0308218 A1Published application
Fusion proteins of il-24 and immunostimulatory cytokines, nk cells expressing il-24 or fusion proteins, and methods of use thereof
AssigneeVirginia Commonwealth University
InventorsPaul B. Fisher, Swadesh Das, Amit Kumar, Luni Emdad
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Abstract
The present disclosure provides fusion proteins of IL-24 with immunostimulatory cytokines and natural killer (NK) cells genetically engineered to express IL-24 or such fusion proteins, and methods of using these proteins and cells.
Claims65
A fusion protein comprising an IL-24 polypeptide and an immunostimulatory cytokine.
An NK cell comprising a nucleic acid encoding an IL-24 polypeptide operably linked to a heterologous transcription control element.
Dependencies are inferred from the claim text.