Systems and methods for targeted breast cancer therapies

A method of treating breast cancer in a mammal, the method comprising:

• delivering an actively targeted liposome to the mammal, the actively targeted liposome comprising:
• a lipid bilayer forming a spherical shell, wherein the spherical shell comprises an interior liposomal cavity,
• a plurality of trastuzumab molecules linked to a surface of the actively targeted liposome, and a chemotherapeutic drug, the chemotherapeutic drug comprising at least one of a hydrophilic chemotherapeutic drug contained within the interior liposomal cavity and a hydrophobic chemotherapeutic drug contained within the lipid bilayer of the actively targeted liposome;
• and
• allowing the actively targeted liposome to circulate throughout a circulatory system of the mammal for a time sufficient to allow aggregation of a therapeutic quantity of actively targeted liposomes at a treatment area comprising a breast cancer;
• and
• applying ultrasound to the treatment area such that the actively targeted liposome is critically disrupted thereby releasing the chemotherapeutic drug in the treatment area.