Method and system for applying pulsed electric fields with high uniformity using charged ring structures
AssigneeThe Phantom Laboratory, Incorporated
InventorRichard Mallozzi
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Abstract
A device, system and method for generating pulsed electric fields with high uniformity are provided. The electric fields occupy a large volume, suitable for placing a human or animal patient. A device for generating the electric fields is provided, which comprises a plurality of ring structures made of an electrically conductive material, wherein the ring structures are charged to different voltage levels. The device generates an electric field of high uniformity in the interior region of the ring structures when pulsed with electrical currents. These electric field pulses, when used in conjunction with pharmacological agents, destroy cancer cells through a process called targeted osmotic lysis.
Claims6
A method for therapeutic treatments via targeted osmotic lysis, comprising administering to a subject pulsed electric fields generated by a device for generating pulsed electric fields, comprising an electrostatic ring unit comprising a driving and sensing circuitry and a plurality of ring structures positioned along the longitudinal axis, wherein the ring structures are made of an electrically conductive material, and wherein the driving and sensing circuitry is configured to charge the ring structures to different voltage levels, wherein the pulsed electric fields are administered at an 18 V/m field amplitude for 2 hours for two successive days.
A method for therapeutic treatments via targeted osmotic lysis, comprising administering to a subject pulsed electric fields generated by a device for generating pulsed electric fields, comprising an electrostatic ring unit comprising a driving and sensing circuitry and a plurality of ring structures positioned along the longitudinal axis, wherein the ring structures are made of an electrically conductive material, and wherein the driving and sensing circuitry is configured to charge the ring structures to different voltage levels, wherein the pulsed electric fields are administered for two successive days and further comprising administering to the subject digoxin, wherein there is a digoxin free period between each 2-day administration of pulsed electric fields.
Dependencies are inferred from the claim text.