A61K 31/663
Compounds having two or more phosphorus acid groups or esters thereof
Official title: Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
A61K31/663 (Compounds having two or more phosphorus acid groups or esters thereof) appears on 475 US grants and 865 published applications in this corpus.
Search patents in A61K- Granted patents
- 475
- Published applications
- 865
- Assignees
- 377
- Inventors
- 1,328
- Latest grant
- 16 Jun 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1992 | 1 | 0 |
| 1993 | 0 | 0 |
| 1994 | 1 | 0 |
| 1995 | 1 | 0 |
| 1996 | 1 | 0 |
| 1997 | 8 | 0 |
| 1998 | 9 | 0 |
| 1999 | 14 | 0 |
| 2000 | 10 | 0 |
| 2001 | 9 | 20 |
| 2002 | 17 | 28 |
| 2003 | 18 | 35 |
| 2004 | 11 | 41 |
| 2005 | 6 | 34 |
| 2006 | 7 | 45 |
| 2007 | 8 | 33 |
| 2008 | 7 | 29 |
| 2009 | 11 | 32 |
| 2010 | 20 | 42 |
| 2011 | 19 | 30 |
| 2012 | 15 | 26 |
| 2013 | 12 | 23 |
| 2014 | 21 | 50 |
| 2015 | 20 | 35 |
| 2016 | 32 | 53 |
| 2017 | 34 | 58 |
| 2018 | 45 | 49 |
| 2019 | 29 | 54 |
| 2020 | 15 | 28 |
| 2021 | 19 | 33 |
| 2022 | 14 | 26 |
| 2023 | 13 | 19 |
| 2024 | 14 | 17 |
| 2025 | 9 | 15 |
| 2026 | 5 | 10 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- Methods of selectively treating complex regional pain syndrome type I (CRPS-I) using bisphosphonate derivatives16 Jun 2026US 12,653,834 B1Ambros Therapeutics, Inc.
- Compositions and methods for treating amyotrophic lateral sclerosis2 Jun 2026US 12,644,122 B2Children's Medical Center Corporation
- Treating inflammation using LLP2A-bisphosphonate conjugates and mesenchymal stem cells7 Apr 2026US 12,594,340 B2The Regents of the University of California
- Phosphonate conjugates and uses thereof7 Apr 2026US 12,595,273 B2
- Methods of treating osteonecrosis with LLP2A-bisphosphonate compounds10 Mar 2026US 12,569,506 B2The Regents of the University of California
- Composition for the treatment of osteoarthrosis1 Oct 2026US 2026/0294958 A1Abiogen Pharma S.P.A.
- Targeting Microbubbles17 Sep 2026US 2026/0273061 A1California Institute of Technology
- Phospholipid compounds and formulations27 Aug 2026US 2026/0248830 A1AVVIO Medical, Inc.
- Phosphonate conjugates and uses thereof25 Jun 2026US 2026/0176295 A1The Translational Genomics Research Institute
- Injectable thermoresponsive hydrogels as a combinatory modality for controlled drug delivery, biomaterial implant and 3d printing bioink14 May 2026US 2026/0131005 A1The University of North Carolina at Chapel Hill
Most cited
By later US patents
- Bone growth factors and inhibitors of bone resorption for promoting bone formation219US 5,118,667 ACeltrix Pharmaceuticals, Inc. · 1992
- Method for inhibiting bone resorption123US 6,015,801 AMerck & Co., Inc. · 2000
- Enteric coated formulation of bishosphonic acid compounds and associated therapeutic methods106US 6,468,559 B1Lipocine Inc. · 2002
- Solid oral dosage form containing an enhancer105US 7,704,977 B2Merrion Research III Limited · 2010
- Compositions for oral administration of zoledronic acid or related compounds for treating disease94US 8,802,658 B2Antecip Bioventures II LLC · 2014