Injectable thermoresponsive hydrogels as a combinatory modality for controlled drug delivery, biomaterial implant and 3d printing bioink
AssigneeThe University of North Carolina at Chapel Hill
InventorsSoumya Rahima Benhabbour, Panita Maturavongsadit
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Abstract
Provided herein are pharmaceutical compositions that include a pharmaceutically active agent, a cellulose nanocrystal or a cellulose nanofiber, a thermogelling biocompatible polymer, and a gelling agent. Such pharmaceutical compositions can be configured as a bioink suitable for 3D printing. Such pharmaceutical compositions are suitable for treating bone disorders, including osteoporosis. Methods of treating Paget's disease, treating or preventing cancer, treating or preventing an infectious disease, and treating or preventing a disorder through regenerative medicine are also provided.
Claims18
1-21. (canceled)
A pharmaceutical composition comprising, the solution comprising:
- a pharmaceutically active agent, wherein the pharmaceutically active agent comprises an agent for treating or preventing a disorder through regenerative medicine;
- a cellulose nanocrystal or a cellulose nanofiber;
- a thermogelling biocompatible polymer, wherein the thermogelling biocompatible polymer is a chitosan or a chitosan derivative;
- and
- a gelling agent.
Dependencies are inferred from the claim text.