Methods of selectively treating complex regional pain syndrome type I (CRPS-I) using bisphosphonate derivatives

A method of selectively treating CRPS Type 1 comprising:

• (A) identifying a patient that has been diagnosed as having CRPS Type 1 as a patient that is likely to have reduction in pain intensity of 50% or more in response to aminobisphosphonate treatment and selecting that patient to receive treatment by confirming that the patient has:
• (i) edema in the affected limb and at least two of the following:
• 1) redness in the affected limb relative to the contralateral limb,
• 2) ≥1° C. increase in temperature on the affected limb relative to the contralateral limb, and
• 3) moderate to severe edema, and
• (ii) increased uptake of a radiolabeled agent in the affected limb relative to the contralateral limb in a triple phase bone scan (TPBS);
• wherein the patient is experiencing a pain intensity greater than 4 on the 11-point numeric rating scale (NRS);
• and
• (B) administering to the selected patient a 400 mg total dose of neridronate, wherein the selected patient achieves a reduction in pain intensity of 50% or more.