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US 12,595,273 B2Granted
Phosphonate conjugates and uses thereof
OwnerHariprasad Vankayalapati, Sunil Sharma +1inventors
InventorsHariprasad Vankayalapati, Sunil Sharma, Alana L. Welm
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Abstract
Phosphonate conjugates, preferably, bisphosphonate conjugates: methods of inhibiting Ron receptor tyrosine kinase and methods of treatment of bone destruction due to cancer or other conditions utilizing the provided phosphonate conjugates.
Claims12
A phosphonate conjugate with compound A, wherein compound A has the following structural formula:
- and wherein the phosphonate is directly conjugated to compound A, and wherein said conjugate is selected from the group consisting of
- and a pharmaceutically acceptable salt or isomer thereof.
Dependencies are inferred from the claim text.