A61K 31/4468
Having a nitrogen directly attached in position 4
Official title: having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
A61K31/4468 (Having a nitrogen directly attached in position 4) appears on 624 US grants and 1,117 published applications in this corpus.
Search patents in A61K- Granted patents
- 624
- Published applications
- 1,117
- Assignees
- 470
- Inventors
- 1,768
- Latest grant
- 6 Oct 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1995 | 2 | 0 |
| 1996 | 1 | 0 |
| 1997 | 4 | 0 |
| 1998 | 4 | 0 |
| 1999 | 11 | 0 |
| 2000 | 13 | 0 |
| 2001 | 14 | 6 |
| 2002 | 12 | 17 |
| 2003 | 15 | 37 |
| 2004 | 13 | 38 |
| 2005 | 9 | 22 |
| 2006 | 7 | 21 |
| 2007 | 6 | 32 |
| 2008 | 3 | 35 |
| 2009 | 7 | 41 |
| 2010 | 19 | 36 |
| 2011 | 14 | 38 |
| 2012 | 20 | 40 |
| 2013 | 24 | 41 |
| 2014 | 43 | 62 |
| 2015 | 27 | 66 |
| 2016 | 39 | 60 |
| 2017 | 45 | 61 |
| 2018 | 35 | 63 |
| 2019 | 48 | 56 |
| 2020 | 38 | 67 |
| 2021 | 34 | 60 |
| 2022 | 27 | 63 |
| 2023 | 32 | 51 |
| 2024 | 21 | 38 |
| 2025 | 23 | 32 |
| 2026 | 14 | 34 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- Benzenesulfonamide derivatives and method for treating cancer6 Oct 2026US 12,751,936 B2Gongwin Biopharm Co., Ltd
- Therapeutics for treatment of COVID-19 symptoms30 Jun 2026US 12,667,581 B2The Texas A&M University System
- Luminally-acting N-(piperidin-4-yl)benzamide derivatives16 Jun 2026US 12,653,815 B2Takeda Pharmaceutical Company Limited
- Piperidine urea derivatives for use as inotropic agents9 Jun 2026US 12,648,941 B2Anacardio AB
- Method of using human spheroids for drug discovery26 May 2026US 12,638,439 B2AXOSIM, Inc.
- Methods of treating diseases and disorders associated with foxp3 expression8 Oct 2026US 2026/0306482 A1Northwestern University
- Cyclohexyl or heterocycloalkyl beta-hydroxy alkyl amines for use in the treatment of hyperglycaemia and disorders characterised by hyperglycaemia17 Sep 2026US 2026/0274785 A1Atrogi AB
- Piperidine Urea Derivatives for Use as Inotropic Agents3 Sep 2026US 2026/0256760 A1Anacardio AB
- Ibogaine analogs as therapeutics for neurological and psychiatric disorders3 Sep 2026US 2026/0256805 A1The Trustees of Columbia University in the City of New York
- Vdac inhibitors for treating inflammatory bowel diseases3 Sep 2026US 2026/0256877 A1The National Institute for Biotechnology In the Negev Ltd.
Most cited
By later US patents
- Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth243US 6,861,053 B1Cedars-Sinai Medical Center · 2005
- Pharmaceutical composition containing acid addition salt of basic drug163US 6,255,502 B1Farmarc Nederland BV · 2001
- Sublingual buccal effervescent159US 6,200,604 B1Cima Labs Inc. · 2001
- Methods and apparatus for improved administration of pharmaceutically active compounds152US 6,245,347 B1Zars, Inc. · 2001
- Methods and devices for delivering opioid analgesics to wounds via a subdermal implant134US 5,919,473 A1999