Luminally-acting N-(piperidin-4-yl)benzamide derivatives

A compound of Formula 1,

• or a pharmaceutically acceptable salt thereof in which:
• m is an integer selected from 0 and 1;
• R1 is methyl and R2 is hydrogen, or R1 and R2 together form an ethane-1,2-diyl which bridges the oxygen and carbon atoms to which R1 and R2 are respectively attached;
• R3 and R4 are each independently selected from hydrogen, halo, C1-4 alkyl and C1-3 alkoxy;
• R5 and R6 are each independently selected from hydrogen and C1-4 alkyl which is unsubstituted or substituted with an optional substituent selected from hydroxy, phosphono, sulfo and amino, wherein the amino optional substituent is unsubstituted or substituted with 1 or 2 optional substituents independently selected from C1-3 alkyl;
• X1 is selected from a bond and methane-1,1-diyl;
• X2 is selected from
• (a) pentane-1,5-diyl which is unsubstituted or substituted with 1 to 5 optional substituents independently selected from halo and C1-3 alkyl, wherein one of the carbon atoms of the pentane-1,5-diyl substituent may be optionally replaced with one oxygen atom, provided the oxygen atom is directly bonded to two carbon atoms within the pentane-1,5-diyl substituent;
• and
• (b) a moiety represented by the formula
• wherein
• Ra and Rb are each hydrogen or together represent oxo;
• and
• q is an integer selected from 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10;
• X3 is selected from
• (a) C1-11 alkanediyl, wherein 0 to 3 carbon atoms of the alkanediyl substituent may be optionally replaced, one-to-one, with oxygen atoms, provided each replacement oxygen atom is directly bonded to two carbon atoms within the alkanediyl substituent and any two replacement oxygen atoms are separated by at least one carbon atom;
• and
• (b) a moiety represented by the formula,
• wherein r is an integer selected from 1, 2, 3, 4, 5, 6 and 7;
• and
• X4 is selected from
• (a) C3-6 alkyl which is substituted with 3 to 6 hydroxy substituents;
• (b) C1-3 alkyl which is substituted with phosphono or sulfo substituents;
• and
• (c) cyclohexyl which is substituted with 3 to 6 substituents independently selected from hydroxy and hydroxymethyl;
• wherein the bracketed moieties in Formula 1 and in the formulas for X2 and X3 are present m, q or r times, respectively, and each on represents a point of attachment in the formulas for X2 and X3.